000143619 001__ 143619
000143619 005__ 20240229112600.0
000143619 0247_ $$2doi$$a10.1093/advances/nmy125
000143619 0247_ $$2pmid$$apmid:31075175
000143619 0247_ $$2ISSN$$a2156-5376
000143619 0247_ $$2ISSN$$a2161-8313
000143619 0247_ $$2altmetric$$aaltmetric:60293387
000143619 037__ $$aDKFZ-2019-01196
000143619 041__ $$aeng
000143619 082__ $$a640
000143619 1001_ $$0P:(DE-HGF)0$$aSowah, Solomon A$$b0$$eFirst author
000143619 245__ $$aEffects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review.
000143619 260__ $$aBethesda, MD$$bASN$$c2019
000143619 3367_ $$2DRIVER$$aarticle
000143619 3367_ $$2DataCite$$aOutput Types/Journal article
000143619 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1567603311_25118$$xReview Article
000143619 3367_ $$2BibTeX$$aARTICLE
000143619 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000143619 3367_ $$00$$2EndNote$$aJournal Article
000143619 520__ $$aShort-chain fatty acids (SCFAs, mainly acetate, propionate, and butyrate), which are primarily derived from the gut microbiome, may exert anti-inflammatory and immunomodulatory effects, and regulate energy homeostasis. It has been suggested that weight loss may affect SCFA metabolism, but a systematic review of intervention studies is lacking. We aimed to systematically assess the effects of dietary, physical activity-based, and surgical weight-loss interventions among overweight [body mass index (BMI) 25-29.9 kg/m2)] or obese (BMI ≥30 kg/m2) adults (≥18 y) on concentrations of acetate, propionate, butyrate, and total SCFAs in blood, urine, or feces. We conducted a systematic literature search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to April 30, 2018 for randomized and nonrandomized weight-loss trials among overweight or obese adults, in which the concentrations of individual and total SCFAs were assessed. A total of 9 studies consisting of 2 randomized parallel-arm trials, 4 crossover trials, and 3 nonrandomized clinical or surgical trials were included. In the majority of studies, changes in fecal SCFA concentrations were assessed, whereas changes in serum SCFAs were reported from 1 trial. Individual and total SCFA concentrations either remained unchanged or decreased significantly following weight loss. Three of the dietary interventions that resulted in decreased SCFA concentrations were low (≤5% of energy) in total carbohydrates. Most of the studies had a high risk of bias. Decreases in SCFA concentrations may accompany weight loss induced by bariatric surgery or dietary restriction among overweight or obese adults, particularly when carbohydrate intake is reduced. However, findings were inconsistent and based on studies with high to unclear risk of bias, and small sample sizes. Because measurements of fecal SCFAs may not be ideal due to limited sample standardization, well-powered trials with repeated blood measurements of SCFAs are required. This review was registered at PROSPERO as CRD42018088716.
000143619 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000143619 588__ $$aDataset connected to CrossRef, PubMed,
000143619 7001_ $$0P:(DE-HGF)0$$aRiedl, Lena$$b1
000143619 7001_ $$0P:(DE-HGF)0$$aDamms-Machado, Antje$$b2
000143619 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron S$$b3$$udkfz
000143619 7001_ $$0P:(DE-He78)ceb74219d144ab5760a228e71440c5ca$$aSchübel, Ruth$$b4$$udkfz
000143619 7001_ $$0P:(DE-He78)9a183bfc8348c1db81a0ecf1458d0708$$aGraf, Mirja$$b5$$udkfz
000143619 7001_ $$aKartal, Ece$$b6
000143619 7001_ $$aZeller, Georg$$b7
000143619 7001_ $$aSchwingshackl, Lukas$$b8
000143619 7001_ $$aStangl, Gabriele I$$b9
000143619 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b10$$udkfz
000143619 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b11$$eLast author$$udkfz
000143619 773__ $$0PERI:(DE-600)2583634-1$$a10.1093/advances/nmy125$$gp. nmy125$$n4$$p673-684$$tAdvances in nutrition$$v10$$x2156-5376$$y2019
000143619 909CO $$ooai:inrepo02.dkfz.de:143619$$pVDB
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)ceb74219d144ab5760a228e71440c5ca$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9a183bfc8348c1db81a0ecf1458d0708$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ
000143619 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000143619 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000143619 9141_ $$y2019
000143619 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bADV NUTR : 2017
000143619 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000143619 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000143619 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000143619 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000143619 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000143619 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000143619 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000143619 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bADV NUTR : 2017
000143619 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lEpidemiologie von Krebserkrankungen$$x0
000143619 980__ $$ajournal
000143619 980__ $$aVDB
000143619 980__ $$aI:(DE-He78)C020-20160331
000143619 980__ $$aUNRESTRICTED