TY  - JOUR
AU  - Sowah, Solomon A
AU  - Riedl, Lena
AU  - Damms-Machado, Antje
AU  - Johnson, Theron S
AU  - Schübel, Ruth
AU  - Graf, Mirja
AU  - Kartal, Ece
AU  - Zeller, Georg
AU  - Schwingshackl, Lukas
AU  - Stangl, Gabriele I
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Effects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review.
JO  - Advances in nutrition
VL  - 10
IS  - 4
SN  - 2156-5376
CY  - Bethesda, MD
PB  - ASN
M1  - DKFZ-2019-01196
SP  - 673-684
PY  - 2019
AB  - Short-chain fatty acids (SCFAs, mainly acetate, propionate, and butyrate), which are primarily derived from the gut microbiome, may exert anti-inflammatory and immunomodulatory effects, and regulate energy homeostasis. It has been suggested that weight loss may affect SCFA metabolism, but a systematic review of intervention studies is lacking. We aimed to systematically assess the effects of dietary, physical activity-based, and surgical weight-loss interventions among overweight [body mass index (BMI) 25-29.9 kg/m2)] or obese (BMI ≥30 kg/m2) adults (≥18 y) on concentrations of acetate, propionate, butyrate, and total SCFAs in blood, urine, or feces. We conducted a systematic literature search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to April 30, 2018 for randomized and nonrandomized weight-loss trials among overweight or obese adults, in which the concentrations of individual and total SCFAs were assessed. A total of 9 studies consisting of 2 randomized parallel-arm trials, 4 crossover trials, and 3 nonrandomized clinical or surgical trials were included. In the majority of studies, changes in fecal SCFA concentrations were assessed, whereas changes in serum SCFAs were reported from 1 trial. Individual and total SCFA concentrations either remained unchanged or decreased significantly following weight loss. Three of the dietary interventions that resulted in decreased SCFA concentrations were low (≤5
LB  - PUB:(DE-HGF)16
C6  - pmid:31075175
DO  - DOI:10.1093/advances/nmy125
UR  - https://inrepo02.dkfz.de/record/143619
ER  -