TY  - JOUR
AU  - Freislederer, Philipp
AU  - von Münchow, Asmus
AU  - Kamp, Florian
AU  - Heinz, Christian
AU  - Gerum, Sabine
AU  - Corradini, Stefanie
AU  - SÖhn, Matthias
AU  - Reiner, Michael
AU  - Roeder, Falk
AU  - Floca, Ralf
AU  - Alber, Markus
AU  - Belka, Claus
AU  - Parodi, Katia
TI  - Comparison of Planned Dose on Different CT Image Sets to Four-dimensional Monte Carlo Dose Recalculation Using the Patients Actual Breathing Trace for Lung Stereotactic Body Radiation Therapy.
JO  - Medical physics
VL  - 46
IS  - 7
SN  - 2473-4209
CY  - College Park, Md.
PB  - AAPM
M1  - DKFZ-2019-01197
SP  - 3268-3277
PY  - 2019
AB  - The need for four-dimensional treatment planning becomes indispensable when it comes to radiation therapy for moving tumors in the thoracic and abdominal regions. The primary purpose of this study is to combine the actual breathing trace during each individual treatment fraction with the Linac's log file information and Monte Carlo 4D dose calculations. We investigated this workow on multiple CT datasets in a clinical environment for stereotactic body radiation therapy (SBRT) treatment planning.We have developed a workow, which allows us to recalculate absorbed dose to a four-dimensional computed tomography (4DCT) dataset using Monte Carlo calculation methods and accumulate all 4D doses in order to compare them to the planned dose using the Linac's log file, a 4DCT dataset, and the patient's actual breathing curve for each individual fraction. For 5 lung patients, 3D-conformal radiation therapy (3D-CRT) and volumetric arc modulated treatment (VMAT) treatment plans were generated on four different CT image datasets: a native free-breathing three-dimensional CT (3DCT), an average intensity projection (AIP) and a maximum intensity projection (MIP) CT both obtained from a 4DCT, and a 3DCT with density overrides based on the 3DCT (DO). The Monte Carlo 4D dose has been calculated on each 4DCT phase using the Linac's log file and the patient's breathing trace as a surrogate for tumor motion and dose was accumulated to the gross tumor volume (GTV) at the 50
LB  - PUB:(DE-HGF)16
C6  - pmid:31074510
DO  - DOI:10.1002/mp.13579
UR  - https://inrepo02.dkfz.de/record/143620
ER  -