TY  - JOUR
AU  - Paramasivam, Nagarajan
AU  - Hübschmann, Daniel
AU  - Toprak, Umut H
AU  - Ishaque, Naveed
AU  - Neidert, Marian
AU  - Schrimpf, Daniel
AU  - Stichel, Damian
AU  - Reuss, David
AU  - Sievers, Philipp
AU  - Reinhardt, Annekathrin
AU  - Wefers, Annika K
AU  - Jones, David T W
AU  - Gu, Zuguang
AU  - Werner, Johannes
AU  - Uhrig, Sebastian
AU  - Wirsching, Hans-Georg
AU  - Schick, Matthias
AU  - Bewerunge-Hudler, Melanie
AU  - Beck, Katja
AU  - Brehmer, Stephanie
AU  - Urbschat, Steffi
AU  - Seiz-Rosenhagen, Marcel
AU  - Hänggi, Daniel
AU  - Herold-Mende, Christel
AU  - Ketter, Ralf
AU  - Eils, Roland
AU  - Ram, Zvi
AU  - Pfister, Stefan M
AU  - Wick, Wolfgang
AU  - Weller, Michael
AU  - Grossmann, Rachel
AU  - von Deimling, Andreas
AU  - Schlesner, Matthias
AU  - Sahm, Felix
TI  - Mutational patterns and regulatory networks in epigenetic subgroups of meningioma.
JO  - Acta neuropathologica
VL  - 138
IS  - 2
SN  - 1432-0533
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2019-01203
SP  - 295-308
PY  - 2019
AB  - DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign 1-3, intermediate A and B, and malignant. Here, we set out to identify subgroup-specific mutational patterns and gene regulation. Whole genome sequencing was performed on 62 samples across all MCs and WHO grades from 62 patients with matched blood control, including 40 sporadic meningiomas and 22 meningiomas arising after radiation (Mrad). RNA sequencing was added for 18 of these cases and chromatin-immunoprecipitation for histone H3 lysine 27 acetylation (H3K27ac) followed by sequencing (ChIP-seq) for 16 samples. Besides the known mutations in meningioma, structural variants were found as the mechanism of NF2 inactivation in a small subset (5
LB  - PUB:(DE-HGF)16
C6  - pmid:31069492
DO  - DOI:10.1007/s00401-019-02008-w
UR  - https://inrepo02.dkfz.de/record/143626
ER  -