%0 Journal Article
%A Gao, Xin
%A Holleczek, Bernd
%A Cuk, Katarina
%A Zhang, Yan
%A Anusruti, Ankita
%A Xuan, Yang
%A Xu, Yiwei
%A Brenner, Hermann
%A Schöttker, Ben
%T Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence.
%J Scientific reports
%V 9
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2019-01206
%P 7109
%D 2019
%X Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2'-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were diagnosed during over 14 years of follow-up. Associations of OxGua levels with cancer outcomes were not observed in the total population in multi-variable adjusted Cox regression models. However, in subgroup analyses, colorectal cancer incidence increased by 8
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31068619
%R 10.1038/s41598-019-42596-x
%U https://inrepo02.dkfz.de/record/143629