TY  - JOUR
AU  - Gao, Xin
AU  - Holleczek, Bernd
AU  - Cuk, Katarina
AU  - Zhang, Yan
AU  - Anusruti, Ankita
AU  - Xuan, Yang
AU  - Xu, Yiwei
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence.
JO  - Scientific reports
VL  - 9
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2019-01206
SP  - 7109
PY  - 2019
AB  - Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2'-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were diagnosed during over 14 years of follow-up. Associations of OxGua levels with cancer outcomes were not observed in the total population in multi-variable adjusted Cox regression models. However, in subgroup analyses, colorectal cancer incidence increased by 8
LB  - PUB:(DE-HGF)16
C6  - pmid:31068619
DO  - DOI:10.1038/s41598-019-42596-x
UR  - https://inrepo02.dkfz.de/record/143629
ER  -