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@ARTICLE{Gao:143629,
      author       = {X. Gao$^*$ and B. Holleczek and K. Cuk$^*$ and Y. Zhang$^*$
                      and A. Anusruti$^*$ and Y. Xuan$^*$ and Y. Xu and H.
                      Brenner$^*$ and B. Schöttker$^*$},
      title        = {{I}nvestigation on potential associations of oxidatively
                      generated {DNA}/{RNA} damage with lung, colorectal, breast,
                      prostate and total cancer incidence.},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2019-01206},
      pages        = {7109},
      year         = {2019},
      abstract     = {Oxidative stress has been linked to cancer development in
                      previous studies. However, the association between
                      pre-diagnostic oxidatively generated DNA/RNA damage levels
                      and incident cancer has rarely been investigated. Urinary
                      oxidized guanine/guanosine (OxGua) concentrations, including
                      8-hydroxy-2'-deoxyguanosine, were assessed in 8,793 older
                      adults in a population-based German cohort. 1,540 incident
                      cancer cases, including 207 lung, 196 colorectal, 218 breast
                      and 245 prostate cancer cases were diagnosed during over 14
                      years of follow-up. Associations of OxGua levels with cancer
                      outcomes were not observed in the total population in
                      multi-variable adjusted Cox regression models. However, in
                      subgroup analyses, colorectal cancer incidence increased by
                      $8\%,$ $9\%$ and $8\%$ with one standard deviation increase
                      in OxGua levels among current non-smokers, female and
                      non-obese participants, respectively. Additionally, among
                      non-smokers, overall and prostate cancer incidences
                      statistically significantly increased by $5\%$ and $13\%$
                      per 1 standard deviation increase in OxGua levels,
                      respectively. In contrast, OxGua levels were inversely
                      associated with the risk of prostate cancer among current
                      smokers. However, none of the subgroup analyses had p-values
                      below a threshold for statistical significance after
                      correction for multiple testing. Thus, results need to be
                      validated in further studies. There might be a pattern that
                      oxidatively generated DNA/RNA damage is a weak cancer risk
                      factor in the absence of other strong risk factors, such as
                      smoking, obesity and male sex.},
      cin          = {C070 / C120 / L101},
      ddc          = {600},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31068619},
      doi          = {10.1038/s41598-019-42596-x},
      url          = {https://inrepo02.dkfz.de/record/143629},
}