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| 001 | 143629 | ||
| 005 | 20240229112600.0 | ||
| 024 | 7 | _ | |a 10.1038/s41598-019-42596-x |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 600 |
| 100 | 1 | _ | |a Gao, Xin |0 P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence. |
| 260 | _ | _ | |a [London] |c 2019 |b Macmillan Publishers Limited, part of Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1562057901_8973 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2'-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were diagnosed during over 14 years of follow-up. Associations of OxGua levels with cancer outcomes were not observed in the total population in multi-variable adjusted Cox regression models. However, in subgroup analyses, colorectal cancer incidence increased by 8%, 9% and 8% with one standard deviation increase in OxGua levels among current non-smokers, female and non-obese participants, respectively. Additionally, among non-smokers, overall and prostate cancer incidences statistically significantly increased by 5% and 13% per 1 standard deviation increase in OxGua levels, respectively. In contrast, OxGua levels were inversely associated with the risk of prostate cancer among current smokers. However, none of the subgroup analyses had p-values below a threshold for statistical significance after correction for multiple testing. Thus, results need to be validated in further studies. There might be a pattern that oxidatively generated DNA/RNA damage is a weak cancer risk factor in the absence of other strong risk factors, such as smoking, obesity and male sex. |
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| 700 | 1 | _ | |a Holleczek, Bernd |b 1 |
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| 700 | 1 | _ | |a Zhang, Yan |0 P:(DE-He78)6a8f87626cb610618a60d742677284cd |b 3 |u dkfz |
| 700 | 1 | _ | |a Anusruti, Ankita |0 P:(DE-He78)c78a3ddbabb2155657210120936e9801 |b 4 |u dkfz |
| 700 | 1 | _ | |a Xuan, Yang |0 P:(DE-He78)ebbb855092f574cef61b6f3ce7640d87 |b 5 |u dkfz |
| 700 | 1 | _ | |a Xu, Yiwei |b 6 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 7 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1038/s41598-019-42596-x |g Vol. 9, no. 1, p. 7109 |0 PERI:(DE-600)2615211-3 |n 1 |p 7109 |t Scientific reports |v 9 |y 2019 |x 2045-2322 |
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