%0 Journal Article
%A Reisinger, Dominik
%A Gojo, Johannes
%A Kasprian, Gregor
%A Haberler, Christine
%A Peyrl, Andreas
%A Azizi, Amedeo A
%A Mayr, Lisa
%A Chocholous, Monika
%A Kool, Marcel
%A Czech, Thomas
%A Slavc, Irene
%T Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage.
%J Neurosurgery
%V 86
%N 4
%@ 0148-396X
%C Oxford
%I Oxford University Press
%M DKFZ-2019-01210
%P 478-484
%D 2020
%Z 2020 Apr 1;86(4):478-484
%X Primary intratumoral hemorrhage as a presenting sign is rare in children with medulloblastomas but may result in severe complications. Given the distinct properties of molecular medulloblastoma subgroups, the impact on neurosurgical practice has still to be defined.To investigate both clinical and radiological presentation of intratumoral hemorrhage in medulloblastoma patients in the context of molecular subgroups.Data of all consecutive medulloblastoma patients treated at our institution between 1993 and 2018 (n = 104) were retrospectively reviewed in respect of clinical and radiological presentation as well as molecular subgroups. For cases with available tumor tissue (n = 86), subgroups were assigned by either 450 K methylation array or immunohistochemistry and CTNNB1 sequencing. Available imaging at diagnosis (n = 62) was reviewed by an experienced neuroradiologist.Within the entire cohort, 4 patients (4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31065705
%R 10.1093/neuros/nyz148
%U https://inrepo02.dkfz.de/record/143633