TY  - JOUR
AU  - Reisinger, Dominik
AU  - Gojo, Johannes
AU  - Kasprian, Gregor
AU  - Haberler, Christine
AU  - Peyrl, Andreas
AU  - Azizi, Amedeo A
AU  - Mayr, Lisa
AU  - Chocholous, Monika
AU  - Kool, Marcel
AU  - Czech, Thomas
AU  - Slavc, Irene
TI  - Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage.
JO  - Neurosurgery
VL  - 86
IS  - 4
SN  - 0148-396X
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2019-01210
SP  - 478-484
PY  - 2020
N1  - 2020 Apr 1;86(4):478-484
AB  - Primary intratumoral hemorrhage as a presenting sign is rare in children with medulloblastomas but may result in severe complications. Given the distinct properties of molecular medulloblastoma subgroups, the impact on neurosurgical practice has still to be defined.To investigate both clinical and radiological presentation of intratumoral hemorrhage in medulloblastoma patients in the context of molecular subgroups.Data of all consecutive medulloblastoma patients treated at our institution between 1993 and 2018 (n = 104) were retrospectively reviewed in respect of clinical and radiological presentation as well as molecular subgroups. For cases with available tumor tissue (n = 86), subgroups were assigned by either 450 K methylation array or immunohistochemistry and CTNNB1 sequencing. Available imaging at diagnosis (n = 62) was reviewed by an experienced neuroradiologist.Within the entire cohort, 4 patients (4
LB  - PUB:(DE-HGF)16
C6  - pmid:31065705
DO  - DOI:10.1093/neuros/nyz148
UR  - https://inrepo02.dkfz.de/record/143633
ER  -