TY  - JOUR
AU  - Brenner, Hermann
AU  - Calderazzo, Silvia
AU  - Seufferlein, Thomas
AU  - Ludwig, Leopold
AU  - Dikopoulos, Nektarios
AU  - Mangold, Jörg
AU  - Böck, Wolfgang
AU  - Stolz, Thomas
AU  - Eisenbach, Thomas
AU  - Block, Thomas
AU  - Kopp-Schneider, Annette
AU  - Czock, David
AU  - Tikk, Kaja
TI  - Effect of a Single Aspirin Dose Prior to Fecal Immunochemical Testing on Test Sensitivity for Detecting Advanced Colorectal Neoplasms: A Randomized Clinical Trial.
JO  - The journal of the American Medical Association
VL  - 321
IS  - 17
SN  - 0098-7484
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2019-01213
SP  - 1686 - 1692
PY  - 2019
AB  - Fecal immunochemical tests for hemoglobin are widely used for colorectal cancer (CRC) screening. Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.To evaluate the potential to increase sensitivity of fecal immunochemical tests by administering a single 300-mg oral aspirin dose 2 days before stool sampling.A randomized, placebo-controlled, double-blind trial was conducted in 14 gastroenterology practices and 4 hospitals in Germany, and included 2422 men and women aged 40 to 80 years scheduled for colonoscopy, with no recent use of aspirin or other drugs with antithrombotic effects (enrollment from June 2013 to November 2016, and final follow-up January 27, 2017).Administration of a single tablet containing 300 mg of aspirin (n = 1208) or placebo (n = 1214) 2 days before fecal sampling for fecal immunochemical test.The primary outcome was sensitivity of a quantitative fecal immunochemical test at 2 predefined cutoffs (10.2 and 17-μg Hb/g stool) for detecting advanced neoplasms (colorectal cancer or advanced adenoma).Among 2422 randomized patients (mean [SD] age, 59.6 [7.9] years; 1219, 50
LB  - PUB:(DE-HGF)16
C6  - pmid:31063574
DO  - DOI:10.1001/jama.2019.4755
UR  - https://inrepo02.dkfz.de/record/143636
ER  -