TY  - JOUR
AU  - Angelova, Assia Ludmilova
AU  - Rommelaere, Jean
TI  - Immune System Stimulation by Oncolytic Rodent Protoparvoviruses.
JO  - Viruses
VL  - 11
IS  - 5
SN  - 1999-4915
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-01220
SP  - 415
PY  - 2019
AB  - Rodent protoparvoviruses (PVs), parvovirus H-1 (H-1PV) in particular, are naturally endowed with oncolytic properties. While being historically described as agents that selectively replicate in and kill cancer cells, recent yet growing evidence demonstrates that these viruses are able to reverse tumor-driven immune suppression through induction of immunogenic tumor cell death, and the establishment of antitumorigenic, proinflammatory milieu within the tumor microenvironment. This review summarizes the most important preclinical proofs of the interplay and the cooperation between PVs and the host immune system. The molecular mechanisms of PV-induced immunostimulation are also discussed. Furthermore, initial encouraging in-human observations from clinical trials and compassionate virus uses are presented, and speak in favor of further H-1PV clinical development as partner drug in combined immunotherapeutic protocols.
LB  - PUB:(DE-HGF)16
C6  - pmid:31060205
DO  - DOI:10.3390/v11050415
UR  - https://inrepo02.dkfz.de/record/143646
ER  -