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@ARTICLE{Angelova:143646,
      author       = {A. L. Angelova$^*$ and J. Rommelaere$^*$},
      title        = {{I}mmune {S}ystem {S}timulation by {O}ncolytic {R}odent
                      {P}rotoparvoviruses.},
      journal      = {Viruses},
      volume       = {11},
      number       = {5},
      issn         = {1999-4915},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2019-01220},
      pages        = {415},
      year         = {2019},
      abstract     = {Rodent protoparvoviruses (PVs), parvovirus H-1 (H-1PV) in
                      particular, are naturally endowed with oncolytic properties.
                      While being historically described as agents that
                      selectively replicate in and kill cancer cells, recent yet
                      growing evidence demonstrates that these viruses are able to
                      reverse tumor-driven immune suppression through induction of
                      immunogenic tumor cell death, and the establishment of
                      antitumorigenic, proinflammatory milieu within the tumor
                      microenvironment. This review summarizes the most important
                      preclinical proofs of the interplay and the cooperation
                      between PVs and the host immune system. The molecular
                      mechanisms of PV-induced immunostimulation are also
                      discussed. Furthermore, initial encouraging in-human
                      observations from clinical trials and compassionate virus
                      uses are presented, and speak in favor of further H-1PV
                      clinical development as partner drug in combined
                      immunotherapeutic protocols.},
      subtyp        = {Review Article},
      cin          = {F010},
      ddc          = {050},
      cid          = {I:(DE-He78)F010-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31060205},
      doi          = {10.3390/v11050415},
      url          = {https://inrepo02.dkfz.de/record/143646},
}