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@ARTICLE{Law:143669,
      author       = {P. J. Law and M. Timofeeva and C. Fernandez-Rozadilla and
                      P. Broderick and J. Studd and J. Fernandez-Tajes and S.
                      Farrington and V. Svinti and C. Palles and G. Orlando and A.
                      Sud and A. Holroyd and S. Penegar and E. Theodoratou and P.
                      Vaughan-Shaw and H. Campbell and L. Zgaga and C. Hayward and
                      A. Campbell and S. Harris and I. J. Deary and J. Starr and
                      L. Gatcombe and M. Pinna and S. Briggs and L. Martin and E.
                      Jaeger and A. Sharma-Oates and J. East and S. Leedham and R.
                      Arnold and E. Johnstone and H. Wang and D. Kerr and R. Kerr
                      and T. Maughan and R. Kaplan and N. Al-Tassan and K. Palin
                      and U. A. Hänninen and T. Cajuso and T. Tanskanen and J.
                      Kondelin and E. Kaasinen and A.-P. Sarin and J. G. Eriksson
                      and H. Rissanen and P. Knekt and E. Pukkala and P.
                      Jousilahti and V. Salomaa and S. Ripatti and A. Palotie and
                      L. Renkonen-Sinisalo and A. Lepistö and J. Böhm and J.-P.
                      Mecklin and D. D. Buchanan and A.-K. Win and J. Hopper and
                      M. E. Jenkins and N. M. Lindor and P. A. Newcomb and S.
                      Gallinger and D. Duggan and G. Casey and P. Hoffmann and M.
                      M. Nöthen and K.-H. Jöckel and D. F. Easton and P. D. P.
                      Pharoah and J. Peto and F. Canzian$^*$ and A. Swerdlow and
                      R. A. Eeles and Z. Kote-Jarai and K. Muir and N. Pashayan
                      and A. Harkin and K. Allan and J. McQueen and J. Paul and T.
                      Iveson and M. Saunders and K. Butterbach$^*$ and J.
                      Chang-Claude$^*$ and M. Hoffmeister$^*$ and H. Brenner$^*$
                      and I. Kirac and P. Matošević and P. Hofer and S. Brezina
                      and A. Gsur and J. P. Cheadle and L. A. Aaltonen and I.
                      Tomlinson and R. S. Houlston and M. G. Dunlop and B. E.
                      Henderson and C. A. Haiman and F. R. Schumacher and A. A. Al
                      Olama and S. Benlloch and S. I. Berndt and D. V. Conti and
                      F. Wiklund and S. Chanock and S. Gapstur and V. L. Stevens
                      and C. M. Tangen and J. Batra and J. Clements and H.
                      Gronberg and J. Schleutker and D. Albanes and A. Wolk and C.
                      West and L. Mucci and G. Cancel-Tassin and S. Koutros and K.
                      D. Sorensen and E. M. Grindedal and D. E. Neal and F. C.
                      Hamdy and J. L. Donovan and R. C. Travis and R. J. Hamilton
                      and S. A. Ingles and B. S. Rosenstein and Y.-J. Lu and G. G.
                      Giles and A. S. Kibel and A. Vega and M. Kogevinas and K. L.
                      Penney and J. Y. Park and J. L. Stanford and C. Cybulski and
                      B. G. Nordestgaard and C. Maier and J. Kim and E. M. John
                      and M. R. Teixeira and S. L. Neuhausen and K. De Ruyck and
                      A. Razack and L. F. Newcomb and M. Gamulin and R. Kaneva and
                      N. Usmani and F. Claessens and P. A. Townsend and M.
                      Gago-Dominguez and M. J. Roobol and F. Menegaux and K.-T.
                      Khaw and L. Cannon-Albright and H. Pandha and S. N.
                      Thibodeau},
      collaboration = {P. consortium},
      title        = {{A}ssociation analyses identify 31 new risk loci for
                      colorectal cancer susceptibility.},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2019-01243},
      pages        = {2154},
      year         = {2019},
      abstract     = {Colorectal cancer (CRC) is a leading cause of
                      cancer-related death worldwide, and has a strong heritable
                      basis. We report a genome-wide association analysis of
                      34,627 CRC cases and 71,379 controls of European ancestry
                      that identifies SNPs at 31 new CRC risk loci. We also
                      identify eight independent risk SNPs at the new and
                      previously reported European CRC loci, and a further nine
                      CRC SNPs at loci previously only identified in Asian
                      populations. We use in situ promoter capture Hi-C (CHi-C),
                      gene expression, and in silico annotation methods to
                      identify likely target genes of CRC SNPs. Whilst these new
                      SNP associations implicate target genes that are enriched
                      for known CRC pathways such as Wnt and BMP, they also
                      highlight novel pathways with no prior links to colorectal
                      tumourigenesis. These findings provide further insight into
                      CRC susceptibility and enhance the prospects of applying
                      genetic risk scores to personalised screening and
                      prevention.},
      cin          = {C055 / C070 / C120 / C020 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31089142},
      pmc          = {pmc:PMC6517433},
      doi          = {10.1038/s41467-019-09775-w},
      url          = {https://inrepo02.dkfz.de/record/143669},
}