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000143670 1001_ $$aHolzer, Kerstin$$b0
000143670 245__ $$aNucleoporin Nup155 is part of the p53 network in liver cancer.
000143670 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000143670 520__ $$aCancer-relevant signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear pore complex (NPC). However, mechanisms by which individual NPC components (Nups) participate in the regulation of these pathways remain poorly understood. We discover by integrating large scale proteomics, polysome fractionation and a focused RNAi approach that Nup155 controls mRNA translation of p21 (CDKN1A), a key mediator of the p53 response. The underlying mechanism involves transcriptional regulation of the putative tRNA and rRNA methyltransferase FTSJ1 by Nup155. Furthermore, we observe that Nup155 and FTSJ1 are p53 repression targets and accordingly find a correlation between the p53 status, Nup155 and FTSJ1 expression in murine and human hepatocellular carcinoma. Our data suggest an unanticipated regulatory network linking translational control by and repression of a structural NPC component modulating the p53 pathway through its effectors.
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000143670 7001_ $$aOri, Alessandro$$b1
000143670 7001_ $$aCooke, Amy$$b2
000143670 7001_ $$0P:(DE-HGF)0$$aDauch, Daniel$$b3
000143670 7001_ $$aDrucker, Elisabeth$$b4
000143670 7001_ $$aRiemenschneider, Philip$$b5
000143670 7001_ $$aAndres-Pons, Amparo$$b6
000143670 7001_ $$aDiGuilio, Amanda L$$b7
000143670 7001_ $$aMackmull, Marie-Therese$$b8
000143670 7001_ $$00000-0002-7441-7867$$aBaßler, Jochen$$b9
000143670 7001_ $$00000-0002-5333-5942$$aRoessler, Stephanie$$b10
000143670 7001_ $$aBreuhahn, Kai$$b11
000143670 7001_ $$0P:(DE-He78)1ba2900406378e069d32db376c7818db$$aZender, Lars$$b12
000143670 7001_ $$aGlavy, Joseph S$$b13
000143670 7001_ $$aDombrowski, Frank$$b14
000143670 7001_ $$00000-0002-4535-8255$$aHurt, Ed$$b15
000143670 7001_ $$0P:(DE-HGF)0$$aSchirmacher, Peter$$b16
000143670 7001_ $$00000-0002-7397-1321$$aBeck, Martin$$b17
000143670 7001_ $$aSinger, Stephan$$b18
000143670 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-10133-z$$gVol. 10, no. 1, p. 2147$$n1$$p2147$$tNature Communications$$v10$$x2041-1723$$y2019
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