TY  - JOUR
AU  - Holzer, Kerstin
AU  - Ori, Alessandro
AU  - Cooke, Amy
AU  - Dauch, Daniel
AU  - Drucker, Elisabeth
AU  - Riemenschneider, Philip
AU  - Andres-Pons, Amparo
AU  - DiGuilio, Amanda L
AU  - Mackmull, Marie-Therese
AU  - Baßler, Jochen
AU  - Roessler, Stephanie
AU  - Breuhahn, Kai
AU  - Zender, Lars
AU  - Glavy, Joseph S
AU  - Dombrowski, Frank
AU  - Hurt, Ed
AU  - Schirmacher, Peter
AU  - Beck, Martin
AU  - Singer, Stephan
TI  - Nucleoporin Nup155 is part of the p53 network in liver cancer.
JO  - Nature Communications
VL  - 10
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2019-01244
SP  - 2147
PY  - 2019
AB  - Cancer-relevant signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear pore complex (NPC). However, mechanisms by which individual NPC components (Nups) participate in the regulation of these pathways remain poorly understood. We discover by integrating large scale proteomics, polysome fractionation and a focused RNAi approach that Nup155 controls mRNA translation of p21 (CDKN1A), a key mediator of the p53 response. The underlying mechanism involves transcriptional regulation of the putative tRNA and rRNA methyltransferase FTSJ1 by Nup155. Furthermore, we observe that Nup155 and FTSJ1 are p53 repression targets and accordingly find a correlation between the p53 status, Nup155 and FTSJ1 expression in murine and human hepatocellular carcinoma. Our data suggest an unanticipated regulatory network linking translational control by and repression of a structural NPC component modulating the p53 pathway through its effectors.
LB  - PUB:(DE-HGF)16
C6  - pmid:31089132
C2  - pmc:PMC6517424
DO  - DOI:10.1038/s41467-019-10133-z
UR  - https://inrepo02.dkfz.de/record/143670
ER  -