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@ARTICLE{Holzer:143670,
      author       = {K. Holzer and A. Ori and A. Cooke and D. Dauch$^*$ and E.
                      Drucker and P. Riemenschneider and A. Andres-Pons and A. L.
                      DiGuilio and M.-T. Mackmull and J. Baßler and S. Roessler
                      and K. Breuhahn and L. Zender$^*$ and J. S. Glavy and F.
                      Dombrowski and E. Hurt and P. Schirmacher and M. Beck and S.
                      Singer},
      title        = {{N}ucleoporin {N}up155 is part of the p53 network in liver
                      cancer.},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2019-01244},
      pages        = {2147},
      year         = {2019},
      abstract     = {Cancer-relevant signalling pathways rely on bidirectional
                      nucleocytoplasmic transport events through the nuclear pore
                      complex (NPC). However, mechanisms by which individual NPC
                      components (Nups) participate in the regulation of these
                      pathways remain poorly understood. We discover by
                      integrating large scale proteomics, polysome fractionation
                      and a focused RNAi approach that Nup155 controls mRNA
                      translation of p21 (CDKN1A), a key mediator of the p53
                      response. The underlying mechanism involves transcriptional
                      regulation of the putative tRNA and rRNA methyltransferase
                      FTSJ1 by Nup155. Furthermore, we observe that Nup155 and
                      FTSJ1 are p53 repression targets and accordingly find a
                      correlation between the p53 status, Nup155 and FTSJ1
                      expression in murine and human hepatocellular carcinoma. Our
                      data suggest an unanticipated regulatory network linking
                      translational control by and repression of a structural NPC
                      component modulating the p53 pathway through its effectors.},
      cin          = {V076 / L801},
      ddc          = {500},
      cid          = {I:(DE-He78)V076-20160331 / I:(DE-He78)L801-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31089132},
      pmc          = {pmc:PMC6517424},
      doi          = {10.1038/s41467-019-10133-z},
      url          = {https://inrepo02.dkfz.de/record/143670},
}