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@ARTICLE{Platten:143705,
      author       = {M. Platten$^*$ and E. A. A. Nollen and U. F. Röhrig and F.
                      Fallarino and C. Opitz$^*$},
      title        = {{T}ryptophan metabolism as a common therapeutic target in
                      cancer, neurodegeneration and beyond.},
      journal      = {Nature reviews / Drug discovery Drug discovery [...]},
      volume       = {18},
      number       = {5},
      issn         = {1474-1784},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2019-01278},
      pages        = {379 - 401},
      year         = {2019},
      abstract     = {L-Tryptophan (Trp) metabolism through the kynurenine
                      pathway (KP) is involved in the regulation of immunity,
                      neuronal function and intestinal homeostasis. Imbalances in
                      Trp metabolism in disorders ranging from cancer to
                      neurodegenerative disease have stimulated interest in
                      therapeutically targeting the KP, particularly the main
                      rate-limiting enzymes indoleamine-2,3-dioxygenase 1 (IDO1),
                      IDO2 and tryptophan-2,3-dioxygenase (TDO) as well as
                      kynurenine monooxygenase (KMO). However, although
                      small-molecule IDO1 inhibitors showed promise in early-stage
                      cancer immunotherapy clinical trials, a phase III trial was
                      negative. This Review summarizes the physiological and
                      pathophysiological roles of Trp metabolism, highlighting the
                      vast opportunities and challenges for drug development in
                      multiple diseases.},
      subtyp        = {Review Article},
      cin          = {D170 / B350 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)D170-20160331 / I:(DE-He78)B350-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30760888},
      doi          = {10.1038/s41573-019-0016-5},
      url          = {https://inrepo02.dkfz.de/record/143705},
}