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000143742 0247_ $$2doi$$a10.1111/ecc.13055
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000143742 0247_ $$2ISSN$$a0961-5423
000143742 0247_ $$2ISSN$$a1365-2354
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000143742 1001_ $$aHimbert, Caroline$$b0
000143742 245__ $$aInflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study.
000143742 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2019
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000143742 520__ $$aCancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue.
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000143742 7001_ $$aOse, Jennifer$$b1
000143742 7001_ $$aLin, Tengda$$b2
000143742 7001_ $$aWarby, Christy A$$b3
000143742 7001_ $$aGigic, Biljana$$b4
000143742 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b5$$udkfz
000143742 7001_ $$aSchrotz-King, Petra$$b6
000143742 7001_ $$aAbbenhardt-Martin, Clare$$b7
000143742 7001_ $$aZielske, Lin$$b8
000143742 7001_ $$aBoehm, Juergen$$b9
000143742 7001_ $$00000-0001-7641-059X$$aUlrich, Cornelia M$$b10
000143742 773__ $$0PERI:(DE-600)2020234-9$$a10.1111/ecc.13055$$gp. e13055 -$$n4$$pe13055$$tEuropean journal of cancer care$$v28$$x1365-2354$$y2019
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