TY  - JOUR
AU  - Himbert, Caroline
AU  - Ose, Jennifer
AU  - Lin, Tengda
AU  - Warby, Christy A
AU  - Gigic, Biljana
AU  - Steindorf, Karen
AU  - Schrotz-King, Petra
AU  - Abbenhardt-Martin, Clare
AU  - Zielske, Lin
AU  - Boehm, Juergen
AU  - Ulrich, Cornelia M
TI  - Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study.
JO  - European journal of cancer care
VL  - 28
IS  - 4
SN  - 1365-2354
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DKFZ-2019-01311
SP  - e13055
PY  - 2019
AB  - Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue.
LB  - PUB:(DE-HGF)16
C6  - pmid:31016796
DO  - DOI:10.1111/ecc.13055
UR  - https://inrepo02.dkfz.de/record/143742
ER  -