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@ARTICLE{Himbert:143742,
      author       = {C. Himbert and J. Ose and T. Lin and C. A. Warby and B.
                      Gigic and K. Steindorf$^*$ and P. Schrotz-King and C.
                      Abbenhardt-Martin and L. Zielske and J. Boehm and C. M.
                      Ulrich},
      title        = {{I}nflammation- and angiogenesis-related biomarkers are
                      correlated with cancer-related fatigue in colorectal cancer
                      patients: {R}esults from the {C}olo{C}are {S}tudy.},
      journal      = {European journal of cancer care},
      volume       = {28},
      number       = {4},
      issn         = {1365-2354},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2019-01311},
      pages        = {e13055},
      year         = {2019},
      abstract     = {Cancer-related fatigue is one of the most common side
                      effects of colorectal cancer treatment and is affected by
                      biomedical factors. We investigated the association of
                      inflammation- and angiogenesis-related biomarkers with
                      cancer-related fatigue. Pre-surgery (baseline) serum samples
                      were obtained from n = 236 newly diagnosed colorectal
                      cancer patients. Meso Scale Discovery assays were performed
                      to measure levels of biomarkers for inflammation and
                      angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1,
                      TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed
                      with the EORTC QLQ-30 questionnaire at baseline and 6 and
                      12 months post-surgery. We tested associations using
                      Spearman's partial correlations and logistic regression
                      analyses, adjusting for age, sex and body mass index.
                      sICAM-1 and VEGFD showed a significant positive correlation
                      with cancer-related fatigue at baseline and 6-, and 12-month
                      follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24,
                      p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20,
                      p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01
                      respectively). Biomarkers of inflammation and angiogenesis
                      measured prior to surgery are associated with cancer-related
                      fatigue in colorectal cancer patients throughout various
                      time points. Our results suggest the involvement of
                      overexpressed sICAM-1 and VEGFD in the development of
                      fatigue.},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31016796},
      doi          = {10.1111/ecc.13055},
      url          = {https://inrepo02.dkfz.de/record/143742},
}