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| Home > Publications database > Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study. > print |
| Home > Publications database > Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study. > print |
| 001 | 143742 | ||
| 005 | 20240229112606.0 | ||
| 024 | 7 | _ | |a 10.1111/ecc.13055 |2 doi |
| 024 | 7 | _ | |a pmid:31016796 |2 pmid |
| 024 | 7 | _ | |a 0961-5423 |2 ISSN |
| 024 | 7 | _ | |a 1365-2354 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2019-01311 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Himbert, Caroline |b 0 |
| 245 | _ | _ | |a Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study. |
| 260 | _ | _ | |a Oxford [u.a.] |c 2019 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1573738030_29982 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Ose, Jennifer |b 1 |
| 700 | 1 | _ | |a Lin, Tengda |b 2 |
| 700 | 1 | _ | |a Warby, Christy A |b 3 |
| 700 | 1 | _ | |a Gigic, Biljana |b 4 |
| 700 | 1 | _ | |a Steindorf, Karen |0 P:(DE-He78)a0c2037d9054be26907a05ae520d5756 |b 5 |u dkfz |
| 700 | 1 | _ | |a Schrotz-King, Petra |b 6 |
| 700 | 1 | _ | |a Abbenhardt-Martin, Clare |b 7 |
| 700 | 1 | _ | |a Zielske, Lin |b 8 |
| 700 | 1 | _ | |a Boehm, Juergen |b 9 |
| 700 | 1 | _ | |a Ulrich, Cornelia M |0 0000-0001-7641-059X |b 10 |
| 773 | _ | _ | |a 10.1111/ecc.13055 |g p. e13055 - |0 PERI:(DE-600)2020234-9 |n 4 |p e13055 |t European journal of cancer care |v 28 |y 2019 |x 1365-2354 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)a0c2037d9054be26907a05ae520d5756 |
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| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EUR J CANCER CARE : 2017 |
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