%0 Journal Article
%A Peters, Andreas S
%A Wortmann, Markus
%A Fleming, Thomas H
%A Nawroth, Peter P
%A Bruckner, Thomas
%A Böckler, Dittmar
%A Hakimi, Maani
%T Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions.
%J Vasa
%V 48
%N 2
%@ 1664-2872
%C Göttingen [u.a.]
%I Huber
%M DKFZ-2019-01322
%P 186 - 192
%D 2019
%X The enzyme glyoxalase1 (GLO1) is the main opponent in the degradation of the reactive metabolite methylglyoxal (MG), which by glycation of macromolecules is involved in atherogenesis. Reduced GLO1-activity in atherosclerotic tissue is known to be associated with diabetes. It has been shown that treatment of patients with type 2 diabetes with metformin leads to increased GLO1-activity in peripheral-blood-cells. The aim of this study was to evaluate whether metformin treatment increases GLO1-activity in atherosclerotic lesions of patients with type 2 diabetes.Patients with type 2 diabetes and carotid artery disease were included into the study prospectively. Type of diabetes-medication was documented upon admission along with demographic and clinical history. Using shock frozen endarterectomy-derived carotid artery plaques, GLO1-activity as well as protein expression was measured by a spectophotometric assay and western-blotting respectively.33 patients (76 
%K Metformin (NLM Chemicals)
%K Lactoylglutathione Lyase (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30421661
%R 10.1024/0301-1526/a000762
%U https://inrepo02.dkfz.de/record/143753