%0 Journal Article
%A Assi, Nada
%A Rinaldi, Sabina
%A Viallon, Vivian
%A Dashti, S Ghazaleh
%A Dossus, Laure
%A Fournier, Agnès
%A Cervenka, Iris
%A Kvaskoff, Marina
%A Turzanski-Fortner, Renée
%A Bergmann, Manuela
%A Boeing, Heiner
%A Panico, Salvatore
%A Ricceri, Fulvio
%A Palli, Domenico
%A Tumino, Rosario
%A Grioni, Sara
%A Sánchez Pérez, María José
%A Chirlaque, María-Dolores
%A Bonet, Catalina
%A Gurrea, Aurelio Barricarte
%A Amiano Etxezarreta, Pilar
%A Merino, Susana
%A Bueno de Mesquita, H Bas
%A van Gils, Carla H
%A Onland-Moret, Charlotte
%A Tjønneland, Anne
%A Overvad, Kim
%A Trichopoulou, Antonia
%A Martimianaki, Georgia
%A Karakatsani, Anna
%A Key, Tim
%A Christakoudi, Sofia
%A Ellingjord-Dale, Merete
%A Tsilidis, Kostas
%A Riboli, Elio
%A Kaaks, Rudolf
%A Gunter, Marc J
%A Ferrari, Pietro
%T Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC cohort.
%J International journal of cancer
%V 146
%N 3
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2019-01356
%P 759-768
%D 2020
%Z 2020 Feb 1;146(3):759-768
%X Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. An alcohol-related hormonal signature, obtained by partial least square (PLS) regression, was evaluated as a potential mediator. Total (TE), natural direct and natural indirect effects (NIE) were estimated. Alcohol intake was positively associated with overall BC risk and specifically with estrogen receptor-positive tumors with respectively TE = 1.17(95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30968961
%R 10.1002/ijc.32324
%U https://inrepo02.dkfz.de/record/143787