TY  - JOUR
AU  - Assi, Nada
AU  - Rinaldi, Sabina
AU  - Viallon, Vivian
AU  - Dashti, S Ghazaleh
AU  - Dossus, Laure
AU  - Fournier, Agnès
AU  - Cervenka, Iris
AU  - Kvaskoff, Marina
AU  - Turzanski-Fortner, Renée
AU  - Bergmann, Manuela
AU  - Boeing, Heiner
AU  - Panico, Salvatore
AU  - Ricceri, Fulvio
AU  - Palli, Domenico
AU  - Tumino, Rosario
AU  - Grioni, Sara
AU  - Sánchez Pérez, María José
AU  - Chirlaque, María-Dolores
AU  - Bonet, Catalina
AU  - Gurrea, Aurelio Barricarte
AU  - Amiano Etxezarreta, Pilar
AU  - Merino, Susana
AU  - Bueno de Mesquita, H Bas
AU  - van Gils, Carla H
AU  - Onland-Moret, Charlotte
AU  - Tjønneland, Anne
AU  - Overvad, Kim
AU  - Trichopoulou, Antonia
AU  - Martimianaki, Georgia
AU  - Karakatsani, Anna
AU  - Key, Tim
AU  - Christakoudi, Sofia
AU  - Ellingjord-Dale, Merete
AU  - Tsilidis, Kostas
AU  - Riboli, Elio
AU  - Kaaks, Rudolf
AU  - Gunter, Marc J
AU  - Ferrari, Pietro
TI  - Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC cohort.
JO  - International journal of cancer
VL  - 146
IS  - 3
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2019-01356
SP  - 759-768
PY  - 2020
N1  - 2020 Feb 1;146(3):759-768
AB  - Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. An alcohol-related hormonal signature, obtained by partial least square (PLS) regression, was evaluated as a potential mediator. Total (TE), natural direct and natural indirect effects (NIE) were estimated. Alcohol intake was positively associated with overall BC risk and specifically with estrogen receptor-positive tumors with respectively TE = 1.17(95
LB  - PUB:(DE-HGF)16
C6  - pmid:30968961
DO  - DOI:10.1002/ijc.32324
UR  - https://inrepo02.dkfz.de/record/143787
ER  -