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@ARTICLE{Grund:143807,
      author       = {T. Grund and Y. Tang$^*$ and D. Benusiglio$^*$ and F.
                      Althammer$^*$ and S. Probst and L. Oppenländer and I. D.
                      Neumann and V. Grinevich$^*$},
      title        = {{C}hemogenetic activation of oxytocin neurons: {T}emporal
                      dynamics, hormonal release, and behavioral consequences.},
      journal      = {Psychoneuroendocrinology},
      volume       = {106},
      issn         = {0306-4530},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2019-01369},
      pages        = {77 - 84},
      year         = {2019},
      abstract     = {Chemogenetics provides cell type-specific remote control of
                      neuronal activity. Here, we describe the application of
                      chemogenetics used to specifically activate oxytocin (OT)
                      neurons as representatives of a unique class of
                      neuroendocrine cells. We injected recombinant
                      adeno-associated vectors, driving the stimulatory subunit
                      hM3Dq of a modified human muscarinic receptor into the rat
                      hypothalamus to achieve cell type-specific expression in OT
                      neurons. As chemogenetic activation of OT neurons has not
                      been reported, we provide systematic analysis of the
                      temporal dynamics of OT neuronal responses in vivo by
                      monitoring calcium fluctuations in OT neurons, and
                      intracerebral as well as peripheral release of OT. We
                      further provide evidence for the efficiency of chemogenetic
                      manipulation at behavioral levels, demonstrating that evoked
                      activation of OT neurons leads to social motivation and
                      anxiolysis. Altogether, our results will be profitable for
                      researchers working on the physiology of neuroendocrine
                      systems, peptidergic modulation of behaviors and
                      translational psychiatry.},
      cin          = {V078},
      ddc          = {610},
      cid          = {I:(DE-He78)V078-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30954921},
      doi          = {10.1016/j.psyneuen.2019.03.019},
      url          = {https://inrepo02.dkfz.de/record/143807},
}