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@ARTICLE{GarroAguilar:143835,
      author       = {Y. Garro-Aguilar and V. Cayssials and D. Achaintre and H.
                      Boeing and F. R. Mancini and Y. Mahamat-Saleh and M.-C.
                      Boutron-Ruault and T. Kühn$^*$ and V. Katzke$^*$ and A.
                      Trichopoulou and A. Karakatsani and P. Thriskos and G.
                      Masala and S. Grioni and M. Santucci de Magistris and R.
                      Tumino and F. Ricceri and I. Huybrechts and A. Agudo and A.
                      Scalbert and R. Zamora-Ros},
      title        = {{C}orrelations between urinary concentrations and dietary
                      intakes of flavonols in the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition ({EPIC})
                      study.},
      journal      = {European journal of nutrition},
      volume       = {59},
      number       = {4},
      issn         = {1436-6215},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2019-01397},
      pages        = {1481-1492},
      year         = {2020},
      note         = {2020 Jun;59(4):1481-1492},
      abstract     = {In this study, we aimed to study the correlation between
                      acute and habitual intakes of flavonols, their main food
                      sources and their 24-h urinary concentrations in an European
                      population.A 24-h dietary recall (24-HDR) and 24-h urine
                      samples were collected on the same day from a convenience
                      subsample of 475 men and women from four countries (France,
                      Italy, Greece and Germany) of the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study. A
                      standardized 24-HDR software and a country/centre-specific
                      validated dietary questionnaire (DQ) were used to collect
                      acute and habitual dietary data, respectively. The intake of
                      dietary flavonols was estimated using the Phenol-Explorer
                      database. Urinary flavonols (quercetin, isorhamnetin, and
                      kaempferol) were analysed using tandem mass spectrometry
                      with a previous enzymatic hydrolysis.Weak partial Spearman
                      correlations between both dietary acute and habitual intake
                      and urinary concentrations of quercetin (both
                      Rpartial ~ 0.3) and total flavonols (both
                      Rpartial ~ 0.2) were observed. No significant
                      correlations were found for kaempferol and isorhamentin.
                      Regarding flavonol-rich foods, weak correlations were found
                      between urinary concentrations of quercetin and total
                      flavonols and the acute intake of onions and garlics,
                      fruits, tea, and herbal tea (all Rpartial ~ 0.2). For
                      habitual intake, statistically significant correlations were
                      only found between urinary quercetin concentration and
                      herbal tea (Rpartial = 0.345) and between urinary total
                      flavonol concentration and tea, and herbal tea consumption
                      (Rpartial ~ 0.2).Our results suggest that urinary
                      quercetin level can be used as potential concentration
                      biomarkers of both acute and habitual quercetin intake,
                      while urinary concentrations of flavonols are unlikely to be
                      useful biomarkers of individual flavonol-rich foods.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31119398},
      doi          = {10.1007/s00394-019-02005-5},
      url          = {https://inrepo02.dkfz.de/record/143835},
}