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@ARTICLE{Wuttke:143856,
      author       = {M. Wuttke and Y. Li and M. Li and K. B. Sieber and M. F.
                      Feitosa and M. Gorski and A. Tin and L. Wang and A. Y. Chu
                      and A. Hoppmann and H. Kirsten and A. Giri and J.-F. Chai
                      and G. Sveinbjornsson and B. O. Tayo and T. Nutile and C.
                      Fuchsberger and J. Marten and M. Cocca and S. Ghasemi and Y.
                      Xu and K. Horn and D. Noce and P. J. van der Most and S.
                      Sedaghat and Z. Yu and M. Akiyama and S. Afaq and T. S.
                      Ahluwalia and P. Almgren and N. Amin and J. Ärnlöv and S.
                      J. L. Bakker and N. Bansal and D. Baptista and S. Bergmann
                      and M. L. Biggs and G. Biino and M. Boehnke and E.
                      Boerwinkle and M. Boissel and E. P. Bottinger and T. S.
                      Boutin and H. Brenner$^*$ and M. Brumat and R. Burkhardt and
                      A. S. Butterworth and E. Campana and A. Campbell and H.
                      Campbell and M. Canouil and R. J. Carroll and E. Catamo and
                      J. C. Chambers and M.-L. Chee and M.-L. Chee and X. Chen and
                      C.-Y. Cheng and Y. Cheng and K. Christensen and R. Cifkova
                      and M. Ciullo and M. P. Concas and J. P. Cook and J. Coresh
                      and T. Corre and C. F. Sala and D. Cusi and J. Danesh and E.
                      W. Daw and M. H. de Borst and A. De Grandi and R. de Mutsert
                      and A. P. J. de Vries and F. Degenhardt and G. Delgado and
                      A. Demirkan and E. Di Angelantonio and K. Dittrich and J.
                      Divers and R. Dorajoo and K.-U. Eckardt and G. Ehret and P.
                      Elliott and K. Endlich and M. K. Evans and J. F. Felix and
                      V. H. X. Foo and O. H. Franco and A. Franke and B. I.
                      Freedman and S. Freitag-Wolf and Y. Friedlander and P.
                      Froguel and R. T. Gansevoort and H. Gao and P. Gasparini and
                      J. M. Gaziano and V. Giedraitis and C. Gieger and G. Girotto
                      and F. Giulianini and M. Gögele and S. D. Gordon and D. F.
                      Gudbjartsson and V. Gudnason and T. Haller and P. Hamet and
                      T. B. Harris and C. A. Hartman and C. Hayward and J. N.
                      Hellwege and C.-K. Heng and A. A. Hicks and E. Hofer and W.
                      Huang and N. Hutri-Kähönen and S.-J. Hwang and M. A. Ikram
                      and O. S. Indridason and E. Ingelsson and M. Ising and V. W.
                      V. Jaddoe and J. Jakobsdottir and J. B. Jonas and P. K.
                      Joshi and N. S. Josyula and B. Jung and M. Kähönen and Y.
                      Kamatani and C. M. Kammerer and M. Kanai and M. Kastarinen
                      and S. M. Kerr and C.-C. Khor and W. Kiess and M. E. Kleber
                      and W. Koenig and J. S. Kooner and A. Körner and P. Kovacs
                      and A. T. Kraja and A. Krajcoviechova and H. Kramer and B.
                      K. Krämer and F. Kronenberg and M. Kubo and B. Kühnel and
                      M. Kuokkanen and J. Kuusisto and M. La Bianca and M. Laakso
                      and L. A. Lange and C. D. Langefeld and J. J. Lee and B.
                      Lehne and T. Lehtimäki and W. Lieb and S.-C. Lim and L.
                      Lind and C. M. Lindgren and J. Liu and J. Liu and M.
                      Loeffler and R. J. F. Loos and S. Lucae and M. A. Lukas and
                      L.-P. Lyytikäinen and R. Mägi and P. K. E. Magnusson and
                      A. Mahajan and N. G. Martin and J. Martins and W. März and
                      D. Mascalzoni and K. Matsuda and C. Meisinger and T.
                      Meitinger and O. Melander and A. Metspalu and E. K.
                      Mikaelsdottir and Y. Milaneschi and K. Miliku and P. P.
                      Mishra and K. L. Mohlke and N. Mononen and G. W. Montgomery
                      and D. O. Mook-Kanamori and J. C. Mychaleckyj and G. N.
                      Nadkarni and M. A. Nalls and M. Nauck and K. Nikus and B.
                      Ning and I. M. Nolte and R. Noordam and J. O'Connell and M.
                      L. O'Donoghue and I. Olafsson and A. J. Oldehinkel and M.
                      Orho-Melander and W. H. Ouwehand and S. Padmanabhan and N.
                      D. Palmer and R. Palsson and B. W. J. H. Penninx and T.
                      Perls and M. Perola and M. Pirastu and N. Pirastu and G.
                      Pistis and A. I. Podgornaia and O. Polasek and B. Ponte and
                      D. J. Porteous and T. Poulain and P. P. Pramstaller and M.
                      H. Preuss and B. P. Prins and M. A. Province and T. J.
                      Rabelink and L. M. Raffield and O. T. Raitakari and D. F.
                      Reilly and R. Rettig and M. Rheinberger and K. M. Rice and
                      P. M. Ridker and F. Rivadeneira and F. Rizzi and D. J.
                      Roberts and A. Robino and P. Rossing and I. Rudan and R.
                      Rueedi and D. Ruggiero and K. A. Ryan and Y. Saba and C.
                      Sabanayagam and V. Salomaa and E. Salvi and K.-U. Saum and
                      H. Schmidt and R. Schmidt and B. Schöttker$^*$ and C.-A.
                      Schulz and N. Schupf and C. M. Shaffer and Y. Shi and A. V.
                      Smith and B. H. Smith and N. Soranzo and C. N. Spracklen and
                      K. Strauch and H. M. Stringham and M. Stumvoll and P. O.
                      Svensson and S. Szymczak and E.-S. Tai and S. M. Tajuddin
                      and N. Y. Q. Tan and K. D. Taylor and A. Teren and Y.-C.
                      Tham and J. Thiery and C. H. L. Thio and H. Thomsen$^*$ and
                      G. Thorleifsson and D. Toniolo and A. Tönjes and J.
                      Tremblay and I. Tzoulaki and A. G. Uitterlinden and S.
                      Vaccargiu and R. M. van Dam and P. van der Harst and C. M.
                      van Duijn and D. R. Velez Edward and N. Verweij and S.
                      Vogelezang and U. Völker and P. Vollenweider and G. Waeber
                      and M. Waldenberger and L. Wallentin and Y. X. Wang and C.
                      Wang and D. M. Waterworth and W. Bin Wei and H. White and J.
                      B. Whitfield and S. H. Wild and J. F. Wilson and M. K.
                      Wojczynski and C. Wong and T.-Y. Wong and L. Xu and Q. Yang
                      and M. Yasuda and L. M. Yerges-Armstrong and W. Zhang and A.
                      B. Zonderman and J. I. Rotter and M. Bochud and B. M. Psaty
                      and V. Vitart and J. G. Wilson and A. Dehghan and A. Parsa
                      and D. I. Chasman and K. Ho and A. P. Morris and O. Devuyst
                      and S. Akilesh and S. A. Pendergrass and X. Sim and C. A.
                      Böger and Y. Okada and T. L. Edwards and H. Snieder and K.
                      Stefansson and A. M. Hung and I. M. Heid and M. Scholz and
                      A. Teumer and A. Köttgen and C. Pattaro},
      collaboration = {L. C. Study and V. A. Million Veteran Program},
      title        = {{A} catalog of genetic loci associated with kidney function
                      from analyses of a million individuals.},
      journal      = {Nature genetics},
      volume       = {51},
      number       = {6},
      issn         = {1546-1718},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2019-01418},
      pages        = {957 - 972},
      year         = {2019},
      abstract     = {Chronic kidney disease (CKD) is responsible for a public
                      health burden with multi-systemic complications. Through
                      trans-ancestry meta-analysis of genome-wide association
                      studies of estimated glomerular filtration rate (eGFR) and
                      independent replication (n = 1,046,070), we identified
                      264 associated loci (166 new). Of these, 147 were likely to
                      be relevant for kidney function on the basis of associations
                      with the alternative kidney function marker blood urea
                      nitrogen (n = 416,178). Pathway and enrichment analyses,
                      including mouse models with renal phenotypes, support the
                      kidney as the main target organ. A genetic risk score for
                      lower eGFR was associated with clinically diagnosed CKD in
                      452,264 independent individuals. Colocalization analyses of
                      associations with eGFR among 783,978 European-ancestry
                      individuals and gene expression across 46 human tissues,
                      including tubulo-interstitial and glomerular kidney
                      compartments, identified 17 genes differentially expressed
                      in kidney. Fine-mapping highlighted missense driver variants
                      in 11 genes and kidney-specific regulatory variants. These
                      results provide a comprehensive priority list of molecular
                      targets for translational research.},
      cin          = {C070 / C050},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C050-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31152163},
      doi          = {10.1038/s41588-019-0407-x},
      url          = {https://inrepo02.dkfz.de/record/143856},
}