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@ARTICLE{Jannasch:143859,
      author       = {F. Jannasch and J. Kröger and C. Agnoli and A. Barricarte
                      and H. Boeing and V. Cayssials and S. Colorado-Yohar and C.
                      C. Dahm and C. Dow and G. Fagherazzi and P. W. Franks and H.
                      Freisling and M. J. Gunter and N. D. Kerrison and T. J. Key
                      and K.-T. Khaw and T. Kühn$^*$ and C. Kyro and F. R.
                      Mancini and O. Mokoroa and P. Nilsson and K. Overvad and D.
                      Palli and S. Panico and J. R. Q. García and O. Rolandsson
                      and C. Sacerdote and M.-J. Sánchez and M. S. Sahrai and R.
                      Schübel$^*$ and I. Sluijs and A. M. W. Spijkerman and A.
                      Tjonneland and T. Y. N. Tong and R. Tumino and E. Riboli and
                      C. Langenberg and S. J. Sharp and N. G. Forouhi and M. B.
                      Schulze and N. J. Wareham},
      title        = {{G}eneralizability of a {D}iabetes-{A}ssociated
                      {C}ountry-{S}pecific {E}xploratory {D}ietary {P}attern {I}s
                      {F}easible {A}cross {E}uropean {P}opulations.},
      journal      = {The journal of nutrition},
      volume       = {149},
      number       = {6},
      issn         = {1541-6100},
      address      = {Bethesda, Md.},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2019-01421},
      pages        = {1047 - 1055},
      year         = {2019},
      abstract     = {Population-specificity of exploratory dietary patterns
                      limits their generalizability in investigations with type 2
                      diabetes incidence.The aim of this study was to derive
                      country-specific exploratory dietary patterns, investigate
                      their association with type 2 diabetes incidence, and
                      replicate diabetes-associated dietary patterns in other
                      countries.Dietary intake data were used, assessed by
                      country-specific questionnaires at baseline of 11,183
                      incident diabetes cases and 14,694 subcohort members (mean
                      age 52.9 y) from 8 countries, nested within the European
                      Prospective Investigation into Cancer and Nutrition study
                      (mean follow-up time 6.9 y). Exploratory dietary patterns
                      were derived by principal component analysis. HRs for
                      incident type 2 diabetes were calculated by
                      Prentice-weighted Cox proportional hazard regression models.
                      Diabetes-associated dietary patterns were simplified or
                      replicated to be applicable in other countries. A
                      meta-analysis across all countries evaluated the
                      generalizability of the diabetes-association.Two dietary
                      patterns per country/UK-center, of which overall 3 dietary
                      patterns were diabetes-associated, were identified. A
                      risk-lowering French dietary pattern was not confirmed
                      across other countries: pooled HRFrance per 1 SD: 1.00;
                      $95\%$ CI: 0.90, 1.10. Risk-increasing dietary patterns,
                      derived in Spain and UK-Norfolk, were confirmed, but only
                      the latter statistically significantly: HRSpain: 1.09;
                      $95\%$ CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; $95\%$ CI:
                      1.04, 1.20. Respectively, this dietary pattern was
                      characterized by relatively high intakes of potatoes,
                      processed meat, vegetable oils, sugar, cake and cookies, and
                      tea.Only few country/center-specific dietary patterns (3 of
                      18) were statistically significantly associated with
                      diabetes incidence in this multicountry European study
                      population. One pattern, whose association with diabetes was
                      confirmed across other countries, showed overlaps in the
                      food groups potatoes and processed meat with identified
                      diabetes-associated dietary patterns from other studies. The
                      study demonstrates that replication of associations of
                      exploratory patterns with health outcomes is feasible and a
                      necessary step to overcome population-specificity in
                      associations from such analyses.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31149710},
      doi          = {10.1093/jn/nxz031},
      url          = {https://inrepo02.dkfz.de/record/143859},
}