000143863 001__ 143863
000143863 005__ 20240229112610.0
000143863 0247_ $$2doi$$a10.1016/j.radonc.2019.04.034
000143863 0247_ $$2pmid$$apmid:31146072
000143863 0247_ $$2ISSN$$a0167-8140
000143863 0247_ $$2ISSN$$a1879-0887
000143863 0247_ $$2altmetric$$aaltmetric:61170031
000143863 037__ $$aDKFZ-2019-01425
000143863 041__ $$aeng
000143863 082__ $$a610
000143863 1001_ $$0P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aSeibold, Petra$$b0$$eFirst author
000143863 245__ $$aREQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer.
000143863 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
000143863 3367_ $$2DRIVER$$aarticle
000143863 3367_ $$2DataCite$$aOutput Types/Journal article
000143863 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634560898_4000
000143863 3367_ $$2BibTeX$$aARTICLE
000143863 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000143863 3367_ $$00$$2EndNote$$aJournal Article
000143863 520__ $$aREQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data.An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated.The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician- (47,025 forms) and patient- (54,901) reported outcomes; 11,563 breast photos; 17,107 DICOMs and 12,684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA (n = 4409) and PAXgene tubes (n = 3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade ≥2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung).The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers.Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short- and long-term quality-of-life. Not all patients are equally sensitive to radiation 'damage' but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensitivity. The purpose of this paper is to provide an overview and summary of the data and material available. In the REQUITE study 4400 breast, prostate and lung cancer patients filled out questionnaires and donated blood. A large amount of data was collected in the same way. With all these data and samples a database and biobank were created that showed it is possible to collect this kind of information in a standardised way across countries. In the future, our database and linked biobank will be a resource for research and validation of clinical predictors and models of radiation sensitivity. REQUITE will also enable a better understanding of how many people suffer with radiotherapy toxicity.
000143863 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000143863 588__ $$aDataset connected to CrossRef, PubMed,
000143863 7001_ $$aWebb, Adam$$b1
000143863 7001_ $$aAguado-Barrera, Miguel E$$b2
000143863 7001_ $$aAzria, David$$b3
000143863 7001_ $$aBourgier, Celine$$b4
000143863 7001_ $$aBrengues, Muriel$$b5
000143863 7001_ $$aBriers, Erik$$b6
000143863 7001_ $$aBultijnck, Renée$$b7
000143863 7001_ $$aCalvo-Crespo, Patricia$$b8
000143863 7001_ $$aCarballo, Ana$$b9
000143863 7001_ $$aChoudhury, Ananya$$b10
000143863 7001_ $$aCicchetti, Alessandro$$b11
000143863 7001_ $$aClaßen, Johannes$$b12
000143863 7001_ $$aDelmastro, Elena$$b13
000143863 7001_ $$aDunning, Alison M$$b14
000143863 7001_ $$aElliott, Rebecca M$$b15
000143863 7001_ $$aFarcy-Jacquet, Marie-Pierre$$b16
000143863 7001_ $$aGabriele, Pietro$$b17
000143863 7001_ $$aGaribaldi, Elisabetta$$b18
000143863 7001_ $$aGómez-Caamaño, Antonio$$b19
000143863 7001_ $$aGutiérrez-Enríquez, Sara$$b20
000143863 7001_ $$aHigginson, Daniel S$$b21
000143863 7001_ $$aJohnson, Kerstie$$b22
000143863 7001_ $$aLobato-Busto, Ramón$$b23
000143863 7001_ $$aMollà, Meritxell$$b24
000143863 7001_ $$0P:(DE-He78)55e70ca2adf894e09e6d90b39fe358e1$$aMüller, Anusha$$b25
000143863 7001_ $$aPayne, Debbie$$b26
000143863 7001_ $$aPeleteiro, Paula$$b27
000143863 7001_ $$aPost, Giselle$$b28
000143863 7001_ $$aRancati, Tiziana$$b29
000143863 7001_ $$0P:(DE-He78)f78fcbd6d9c233854e2bbd62c3c22221$$aRattay, Tim$$b30
000143863 7001_ $$aReyes, Victoria$$b31
000143863 7001_ $$aRosenstein, Barry S$$b32
000143863 7001_ $$aDe Ruysscher, Dirk$$b33
000143863 7001_ $$aDe Santis, Maria Carmen$$b34
000143863 7001_ $$aSchäfer, Jörg$$b35
000143863 7001_ $$aSchnabel, Thomas$$b36
000143863 7001_ $$aSperk, Elena$$b37
000143863 7001_ $$aSymonds, R Paul$$b38
000143863 7001_ $$aStobart, Hilary$$b39
000143863 7001_ $$aTaboada-Valladares, Begoña$$b40
000143863 7001_ $$aTalbot, Christopher J$$b41
000143863 7001_ $$aValdagni, Riccardo$$b42
000143863 7001_ $$aVega, Ana$$b43
000143863 7001_ $$aVeldeman, Liv$$b44
000143863 7001_ $$aWard, Tim$$b45
000143863 7001_ $$aWeißenberger, Christian$$b46
000143863 7001_ $$aWest, Catharine M L$$b47
000143863 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b48$$eLast author
000143863 7001_ $$aconsortium, REQUITE$$b49$$eCollaboration Author
000143863 773__ $$0PERI:(DE-600)1500707-8$$a10.1016/j.radonc.2019.04.034$$gVol. 138, p. 59 - 67$$p59 - 67$$tRadiotherapy and oncology$$v138$$x0167-8140$$y2019
000143863 909CO $$ooai:inrepo02.dkfz.de:143863$$pVDB
000143863 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000143863 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)55e70ca2adf894e09e6d90b39fe358e1$$aDeutsches Krebsforschungszentrum$$b25$$kDKFZ
000143863 9101_ $$0I:(DE-HGF)0$$6P:(DE-He78)f78fcbd6d9c233854e2bbd62c3c22221$$aExternal Institute$$b30$$kExtern
000143863 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b48$$kDKFZ
000143863 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000143863 9141_ $$y2019
000143863 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000143863 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bRADIOTHER ONCOL : 2017
000143863 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000143863 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000143863 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000143863 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000143863 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000143863 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000143863 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000143863 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000143863 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000143863 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000143863 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000143863 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000143863 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000143863 980__ $$ajournal
000143863 980__ $$aVDB
000143863 980__ $$aI:(DE-He78)C020-20160331
000143863 980__ $$aUNRESTRICTED