TY  - JOUR
AU  - Dimou, Niki L
AU  - Papadimitriou, Nikos
AU  - Gill, Dipender
AU  - Christakoudi, Sofia
AU  - Murphy, Neil
AU  - Gunter, Marc J
AU  - Travis, Ruth C
AU  - Key, Tim J
AU  - Fortner, Renee T
AU  - Haycock, Philip C
AU  - Lewis, Sarah J
AU  - Muir, Kenneth
AU  - Martin, Richard M
AU  - Tsilidis, Konstantinos K
TI  - Sex hormone binding globulin and risk of breast cancer: a Mendelian randomization study.
JO  - International journal of epidemiology
VL  - 48
IS  - 3
SN  - 1464-3685
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2019-01428
SP  - 807-816
PY  - 2019
AB  - There are observational data suggesting an inverse association between circulating concentrations of sex hormone binding globulin (SHBG) and risk of postmenopausal breast cancer. However, causality is uncertain and few studies have investigated this association by tumour receptor status. We aimed to investigate these associations under the causal framework of Mendelian randomization (MR).We used summary association estimates extracted from published genome-wide association study (GWAS) meta-analyses for SHBG and breast cancer, to perform two-sample MR analyses. Summary statistics were available for 122 977 overall breast cancer cases, of which 69 501 were estrogen receptor positive (ER+ve) and 21 468 were ER-ve, and 105 974 controls. To control for potential horizontal pleiotropy acting via body mass index (BMI), we performed multivariable inverse-variance weighted (IVW) MR as the main analysis, with the robustness of this approach further tested in sensitivity analyses.The multivariable IVW MR analysis indicated a lower risk of overall (odds ratio [OR]: 0.94; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31143958
DO  - DOI:10.1093/ije/dyz107
UR  - https://inrepo02.dkfz.de/record/143866
ER  -