TY  - JOUR
AU  - Nath, Vishwesh
AU  - Schilling, Kurt G
AU  - Parvathaneni, Prasanna
AU  - Huo, Yuankai
AU  - Blaber, Justin A
AU  - Hainline, Allison E
AU  - Barakovic, Muhamed
AU  - Romascano, David
AU  - Rafael-Patino, Jonathan
AU  - Frigo, Matteo
AU  - Girard, Gabriel
AU  - Thiran, Jean-Philippe
AU  - Daducci, Alessandro
AU  - Rowe, Matt
AU  - Rodrigues, Paulo
AU  - Prčkovska, Vesna
AU  - Aydogan, Dogu B
AU  - Sun, Wei
AU  - Shi, Yonggang
AU  - Parker, William A
AU  - Ould Ismail, Abdol A
AU  - Verma, Ragini
AU  - Cabeen, Ryan P
AU  - Toga, Arthur W
AU  - Newton, Allen T
AU  - Wasserthal, Jakob
AU  - Neher, Peter
AU  - Maier-Hein, Klaus
AU  - Savini, Giovanni
AU  - Palesi, Fulvia
AU  - Kaden, Enrico
AU  - Wu, Ye
AU  - He, Jianzhong
AU  - Feng, Yuanjing
AU  - Paquette, Michael
AU  - Rheault, Francois
AU  - Sidhu, Jasmeen
AU  - Lebel, Catherine
AU  - Leemans, Alexander
AU  - Descoteaux, Maxime
AU  - Dyrby, Tim B
AU  - Kang, Hakmook
AU  - Landman, Bennett A
TI  - Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.
JO  - Journal of magnetic resonance imaging
VL  - 51
IS  - 1
SN  - 1522-2586
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2019-01463
SP  - 234-249
PY  - 2020
N1  - 2020 Jan;51(1):234-249
AB  - Fiber tracking with diffusion-weighted MRI has become an essential tool for estimating in vivo brain white matter architecture. Fiber tracking results are sensitive to the choice of processing method and tracking criteria.To assess the variability for an algorithm in group studies reproducibility is of critical context. However, reproducibility does not assess the validity of the brain connections. Phantom studies provide concrete quantitative comparisons of methods relative to absolute ground truths, yet do no capture variabilities because of in vivo physiological factors. The ISMRM 2017 TraCED challenge was created to fulfill the gap.A systematic review of algorithms and tract reproducibility studies.Single healthy volunteers.3.0T, two different scanners by the same manufacturer. The multishell acquisition included b-values of 1000, 2000, and 3000 s/mm2 with 20, 45, and 64 diffusion gradient directions per shell, respectively.Nine international groups submitted 46 tractography algorithm entries each consisting 16 tracts per scan. The algorithms were assessed using intraclass correlation (ICC) and the Dice similarity measure.Containment analysis was performed to assess if the submitted algorithms had containment within tracts of larger volume submissions. This also serves the purpose to detect if spurious submissions had been made.The top five submissions had high ICC and Dice >0.88. Reproducibility was high within the top five submissions when assessed across sessions or across scanners: 0.87-0.97. Containment analysis shows that the top five submissions are contained within larger volume submissions. From the total of 16 tracts as an outcome relatively the number of tracts with high, moderate, and low reproducibility were 8, 4, and 4.The different methods clearly result in fundamentally different tract structures at the more conservative specificity choices. Data and challenge infrastructure remain available for continued analysis and provide a platform for comparison.5 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019.
LB  - PUB:(DE-HGF)16
C6  - pmid:31179595
DO  - DOI:10.1002/jmri.26794
UR  - https://inrepo02.dkfz.de/record/143905
ER  -