%0 Journal Article
%A Xuan, Yang
%A Gào, Xin
%A Anusruti, Ankita
%A Holleczek, Bernd
%A Jansen, Eugène H J M
%A Muhlack, Dana Clarissa
%A Brenner, Hermann
%A Schöttker, Ben
%T Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies.
%J Diabetes care
%V 42
%N 8
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2019-01477
%P 1436-1445
%D 2019
%X Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been addressed in large cohort studies.Derivatives of reactive oxygen metabolites (d-ROMs) levels, a proxy for the reactive oxygen species burden, and total thiol levels (TTLs), a proxy for the reductive capacity, were measured in 2,125 patients with T2DM from two German cohort studies of almost equal size at baseline and 3-4 years later. Multivariable adjusted Cox proportional hazards models with time-dependent modeled d-ROMs levels and TTLs were used to assess the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality.In total, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were observed during 6-7 years of follow-up, respectively. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in both cohorts, and the pooled hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31167893
%R 10.2337/dc19-0292
%U https://inrepo02.dkfz.de/record/143919