TY  - JOUR
AU  - Xuan, Yang
AU  - Gào, Xin
AU  - Anusruti, Ankita
AU  - Holleczek, Bernd
AU  - Jansen, Eugène H J M
AU  - Muhlack, Dana Clarissa
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies.
JO  - Diabetes care
VL  - 42
IS  - 8
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2019-01477
SP  - 1436-1445
PY  - 2019
AB  - Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been addressed in large cohort studies.Derivatives of reactive oxygen metabolites (d-ROMs) levels, a proxy for the reactive oxygen species burden, and total thiol levels (TTLs), a proxy for the reductive capacity, were measured in 2,125 patients with T2DM from two German cohort studies of almost equal size at baseline and 3-4 years later. Multivariable adjusted Cox proportional hazards models with time-dependent modeled d-ROMs levels and TTLs were used to assess the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality.In total, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were observed during 6-7 years of follow-up, respectively. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in both cohorts, and the pooled hazard ratios (HRs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31167893
DO  - DOI:10.2337/dc19-0292
UR  - https://inrepo02.dkfz.de/record/143919
ER  -