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@ARTICLE{Xuan:143919,
      author       = {Y. Xuan$^*$ and X. Gào$^*$ and A. Anusruti$^*$ and B.
                      Holleczek and E. H. J. M. Jansen and D. C. Muhlack$^*$ and
                      H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{A}ssociation of {S}erum {M}arkers of {O}xidative {S}tress
                      {W}ith {I}ncident {M}ajor {C}ardiovascular {E}vents,
                      {C}ancer {I}ncidence and {A}ll-{C}ause {M}ortality in {T}ype
                      2 {D}iabetes {P}atients: {P}ooled {R}esults {F}rom {T}wo
                      {C}ohort {S}tudies.},
      journal      = {Diabetes care},
      volume       = {42},
      number       = {8},
      issn         = {1935-5548},
      address      = {Alexandria, Va.},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2019-01477},
      pages        = {1436-1445},
      year         = {2019},
      abstract     = {Oxidative stress plays an important role in the
                      pathophysiology of type 2 diabetes mellitus (T2DM). However,
                      associations of biomarkers of oxidative stress with diabetes
                      complications have not yet been addressed in large cohort
                      studies.Derivatives of reactive oxygen metabolites (d-ROMs)
                      levels, a proxy for the reactive oxygen species burden, and
                      total thiol levels (TTLs), a proxy for the reductive
                      capacity, were measured in 2,125 patients with T2DM from two
                      German cohort studies of almost equal size at baseline and
                      3-4 years later. Multivariable adjusted Cox proportional
                      hazards models with time-dependent modeled d-ROMs levels and
                      TTLs were used to assess the associations with incident
                      major cardiovascular events (MCE), cancer incidence, and
                      all-cause mortality.In total, 205, 179, and 394 MCE, cancer,
                      and all-cause mortality cases were observed during 6-7 years
                      of follow-up, respectively. Both oxidative stress biomarkers
                      and the d-ROMs-to-TTL ratio were statistically significantly
                      associated with all-cause mortality in both cohorts, and the
                      pooled hazard ratios (HRs) and $95\%$ CIs for top versus
                      bottom tertiles were 2.10 $(95\%$ CI 1.43, 3.09) for d-ROMs
                      levels, 0.59 (0.40, 0.87) for TTLs, and 2.50 (1.86, 3.36)
                      for d-ROMs-to-TTL ratio. The d-ROMs-to-TTL ratio was also
                      statistically significantly associated with incident MCE for
                      top versus bottom tertile (1.65 [1.07, 2.54]), but this
                      association did not persist after additional adjustment for
                      chronic diseases. No associations with cancer were
                      detected.The observed strong associations of both biomarkers
                      with mortality suggest an important contribution of an
                      imbalanced redox system to the premature mortality of
                      patients with diabetes.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31167893},
      doi          = {10.2337/dc19-0292},
      url          = {https://inrepo02.dkfz.de/record/143919},
}