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@ARTICLE{Thong:143985,
      author       = {M. Thong$^*$ and L. Koch-Gallenkamp$^*$ and L. Jansen$^*$
                      and H. Bertram and A. Eberle and B. Holleczek and M.
                      Waldeyer-Sauerland and A. Waldmann and S. R. Zeissig and H.
                      Brenner$^*$ and V. Arndt$^*$},
      title        = {{A}ge-specific health-related quality of life in long-term
                      and very long-term colorectal cancer survivors versus
                      population controls - a population-based study.},
      journal      = {Acta oncologica},
      volume       = {58},
      number       = {5},
      issn         = {0001-6926},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2019-01542},
      pages        = {801 - 810},
      year         = {2019},
      abstract     = {Background: Previous research suggests an age differential
                      in health-related quality of life (HRQOL) among long-term
                      (5-10 years post-diagnosis, LTS) colorectal cancer (CRC)
                      survivors. Few studies have specifically addressed the
                      association of age differentials with HRQOL for very
                      long-term CRC survivors (>10 years post-diagnosis, VLTS)
                      and non-cancer population controls. We aimed to assess
                      possible deficits in HRQOL of disease-free CRC-LTS and
                      CRC-VLTS in comparison with non-cancer population controls,
                      and whether the observed pattern varies by age and time
                      since diagnosis. Methods: We used data from the CAncEr
                      Survivorship - A multi-Regional (CAESAR+) study in
                      collaboration with five population-based German cancer
                      registries. HRQOL from controls was accessed from the
                      Lebensqualität in DEeutschland (LinDE) study. All
                      respondents completed the European Organization for Research
                      and Treatment of Cancer Quality of Life Core-30
                      questionnaire. We calculated least square means of HRQOL
                      scores. Analyses were adjusted for age, sex, and education,
                      where appropriate. Results: The sample included 862 CRC-LTS,
                      400 CRC-VLTS and 1689 controls. CRC survivors reported
                      overall good HRQOL but significantly poorer social
                      functioning and more problems with dyspnea, constipation,
                      diarrhea and finances than controls. When stratified by age,
                      deficits in functioning and global health, and more problems
                      with symptoms and finances were noted mainly among younger
                      CRC survivors. Further stratification by time since
                      diagnosis showed that similar deficits in HRQOL and symptoms
                      were noted mainly among the younger CRC-LTS group when
                      compared with controls. Generally, CRC-VLTS reported
                      comparable HRQOL to controls. An exception was noted for
                      diarrhea, whereby CRC survivors, regardless of age and time
                      since diagnosis, reported significantly more problems with
                      this symptom than controls. Conclusions: In comparison with
                      non-cancer controls, disease-free CRC survivors reported
                      overall good HRQOL but experience persistent specific
                      detriments in HRQOL many years after diagnosis. In age
                      stratified analyses, HRQOL deficits were noted mainly among
                      younger CRC-LTS.},
      cin          = {C071 / C070 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30736716},
      doi          = {10.1080/0284186X.2018.1557340},
      url          = {https://inrepo02.dkfz.de/record/143985},
}