TY  - JOUR
AU  - Jansen, Henning
AU  - Jaensch, Andrea
AU  - Schöttker, Ben
AU  - Dallmeier, Dhayana
AU  - Schmucker, Roman
AU  - Brenner, Hermann
AU  - Koenig, Wolfgang
AU  - Rothenbacher, Dietrich
TI  - Repeat Measurements of High Sensitivity Troponins for the Prediction of Recurrent Cardiovascular Events in Patients With Established Coronary Heart Disease: An Analysis From the KAROLA Study.
JO  - Journal of the American Heart Association
VL  - 8
IS  - 12
SN  - 2047-9980
CY  - New York, NY
PB  - Association
M1  - DKFZ-2019-01571
SP  - e011882
PY  - 2019
AB  - Background High-sensitivity cardiac troponins T and I (hs- cTnT and hs- cTnI ) are established biomarkers for myocardial injury and used for diagnostic and prognostic purposes. However, whether repeat measurements improve prediction of recurrent cardiovascular disease ( CVD ) events in patients with stable coronary heart disease ( CHD ) after adjustment for several other novel biomarkers remains unclear. Methods and Results We measured both troponins in 873 coronary heart disease patients from the KAROLA (Langzeiterfolge der Kardiologischen Anschlussheilbehandlung) study about 9 weeks after their initial acute event (baseline) and after 12 months, followed them for 12 years, assessed a combined CVD end point, and adjusted for several risk factors. As we found evidence for effect modification, results were stratified according to presence of myocardial infarction at baseline. During follow-up, 186 fatal and non-fatal CVD events occurred. Both baseline and 12-months troponin concentrations were significantly associated with CVD events in patients without myocardial infarction at baseline; in tendency 12 months of troponin showed stronger hazard ratios (hs- cTnT : hazard ratios 1.91 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31189389
DO  - DOI:10.1161/JAHA.118.011882
UR  - https://inrepo02.dkfz.de/record/144020
ER  -