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@ARTICLE{Hilvo:144050,
      author       = {M. Hilvo and P. J. Meikle and E. R. Pedersen and G. S. Tell
                      and I. Dhar and H. Brenner$^*$ and B. Schöttker$^*$ and M.
                      Lääperi and D. Kauhanen and K. M. Koistinen and A. Jylhä
                      and K. Huynh and N. A. Mellett and A. M. Tonkin and D. R.
                      Sullivan and J. Simes and P. Nestel and W. Koenig and D.
                      Rothenbacher and O. Nygård and R. Laaksonen},
      title        = {{D}evelopment and validation of a ceramide- and
                      phospholipid-based cardiovascular risk estimation score for
                      coronary artery disease patients.},
      journal      = {European heart journal},
      volume       = {41},
      number       = {3},
      issn         = {1522-9645},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2019-01601},
      pages        = {371-380},
      year         = {2020},
      note         = {2020 Jan 14;41(3):371-380},
      abstract     = {Distinct ceramide lipids have been shown to predict the
                      risk for cardiovascular disease (CVD) events, especially
                      cardiovascular death. As phospholipids have also been linked
                      with CVD risk, we investigated whether the combination of
                      ceramides with phosphatidylcholines (PCs) would be
                      synergistic in the prediction of CVD events in patients with
                      atherosclerotic coronary heart disease in three independent
                      cohort studies.Ceramides and PCs were analysed using liquid
                      chromatography-mass spectrometry (LC-MS) in three studies:
                      WECAC (The Western Norway Coronary Angiography Cohort)
                      (N = 3789), LIPID (Long-Term Intervention with
                      Pravastatin in Ischaemic Disease) trial (N = 5991), and
                      KAROLA (Langzeiterfolge der KARdiOLogischen
                      Anschlussheilbehandlung) (N = 1023). A simple risk
                      score, based on the ceramides and PCs showing the best
                      prognostic features, was developed in the WECAC study and
                      validated in the two other cohorts. This score was highly
                      significant in predicting CVD mortality [multiadjusted
                      hazard ratios (HRs; $95\%$ confidence interval) per standard
                      deviation were 1.44 (1.28-1.63) in WECAC, 1.47 (1.34-1.61)
                      in the LIPID trial, and 1.69 (1.31-2.17) in KAROLA]. In
                      addition, a combination of the risk score with
                      high-sensitivity troponin T increased the HRs to 1.63
                      (1.44-1.85) and 2.04 (1.57-2.64) in WECAC and KAROLA
                      cohorts, respectively. The C-statistics in WECAC for the
                      risk score combined with sex and age was 0.76 for CVD death.
                      The ceramide-phospholipid risk score showed comparable and
                      synergistic predictive performance with previously published
                      CVD risk models for secondary prevention.A simple ceramide-
                      and phospholipid-based risk score can efficiently predict
                      residual CVD event risk in patients with coronary artery
                      disease.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31209498},
      doi          = {10.1093/eurheartj/ehz387},
      url          = {https://inrepo02.dkfz.de/record/144050},
}