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000144055 0247_ $$2ISSN$$a1873-4626
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000144055 037__ $$aDKFZ-2019-01606
000144055 041__ $$aeng
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000144055 1001_ $$aHeger, Patrick$$b0
000144055 245__ $$aA Systematic Review and Meta-analysis of Physical Exercise Prehabilitation in Major Abdominal Surgery (PROSPERO 2017 CRD42017080366).
000144055 260__ $$aNew York, NY$$bSpringer$$c2020
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000144055 500__ $$a2020 Jun;24(6):1375-1385
000144055 520__ $$aPhysical exercise prehabilitation has been proposed to improve postoperative outcomes in patients undergoing major abdominal surgery. The aim of this systematic review was to investigate the effect of preoperative exercise training compared with standard care on postoperative outcomes in major abdominal surgery.Randomized controlled trials (RCT) comparing prehabilitation with standard care were identified by a systematic literature search of MEDLINE and CENTRAL. Qualitative and quantitative analyses of perioperative outcome data were conducted. Meta-analyses were performed wherever possible and meaningful.A total of eight trials including 442 patients met the inclusion criteria. These trials investigated the effect of prehabilitation in patient cohorts undergoing major liver, colorectal, gastroesophageal, and general abdominal surgery. Quantitative analyses of all included trials showed a significant reduction in postoperative pulmonary complications (OR 0.37; 0.20 to 0.67; p = 0.001) as well as in postoperative overall morbidity (OR 0.52; 0.30 to 0.88; p = 0.01) in the prehabilitation group compared with standard care. The length of hospital stay showed no significant differences between the groups (MD - 0.58; - 1.28 to 0.13; p = 0.11). Risk of bias and methodological quality varied substantially among the trials, most of which were small single-center studies.Prehabilitation including a physical exercise intervention may lead to a reduction of postoperative pulmonary complications as well as less overall morbidity compared with standard care in patients undergoing major abdominal surgery. Further, well-designed RCT are needed to evaluate these potential positive effects in more detail and to identify suitable target populations.PROSPERO 2017 CRD42017080366.
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000144055 7001_ $$aProbst, Pascal$$b1
000144055 7001_ $$aWiskemann, Joachim$$b2
000144055 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b3$$udkfz
000144055 7001_ $$aDiener, Markus K$$b4
000144055 7001_ $$00000-0003-1902-657X$$aMihaljevic, André L$$b5
000144055 773__ $$0PERI:(DE-600)2057634-1$$a10.1007/s11605-019-04287-w$$n6$$p1375-1385$$tJournal of gastrointestinal surgery$$v24$$x1873-4626$$y2020
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