TY  - JOUR
AU  - Haffa, Mariam
AU  - Lin, Tengda
AU  - Holowatyj, Andreana N
AU  - Kratz, Mario
AU  - Toth, Reka
AU  - Benner, Axel
AU  - Gigic, Biljana
AU  - Habermann, Nina
AU  - Schrotz-King, Petra
AU  - Böhm, Jürgen
AU  - Brenner, Hermann
AU  - Schneider, Martin
AU  - Ulrich, Alexis
AU  - Herpel, Esther
AU  - Schirmacher, Peter
AU  - Straub, Beate K
AU  - Nattenmüller, Johanna
AU  - Kauczor, Hans-Ulrich
AU  - Ball, Claudia R
AU  - Ulrich, Cornelia M
AU  - Glimm, Hanno
AU  - Scherer, Dominique
TI  - Transcriptome profiling of adipose tissue reveals depot-specific metabolic alterations among colorectal cancer patients.
JO  - The journal of clinical endocrinology & metabolism
VL  - 104
SN  - 1945-7197
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2019-01609
SP  - 5225-5237
PY  - 2019
AB  - Adipose tissue inflammation and dysregulated energy homeostasis are key mechanisms linking obesity and cancer. Distinct adipose tissue depots strongly differ in their metabolic profiles, however comprehensive studies of depot-specific perturbations among cancer patients are lacking.We compared transcriptome profiles of visceral (VAT) and subcutaneous (SAT) adipose tissue from colorectal cancer patients, and assessed the associations of different anthropometric measures with depot-specific gene expression.Whole transcriptomes of VAT and SAT were measured in 233 patients from the ColoCare Study and visceral and subcutaneous fat area were quantified via computed tomography.VAT compared to SAT showed elevated gene expression of cytokines, cell adhesion molecules and key regulators of metabolic homeostasis. Increased fat area was associated with downregulated lipid and small molecule metabolism and upregulated inflammatory pathways in both compartments. Comparing these patterns between depots proved specific and more pronounced gene expression alterations in SAT and identified unique associations of integrins and lipid metabolism-related enzymes. VAT gene expression patterns that were associated with visceral fat area poorly overlapped with patterns associated with self-reported body mass index (BMI). However, subcutaneous fat area and BMI showed similar associations with SAT gene expression.This large-scale human study demonstrates pronounced disparities between distinct adipose tissue depots and reveals that BMI poorly correlates with fat mass-associated changes in VAT. Together, these results provide crucial evidence for the necessity to differentiate between distinct adipose tissue depots for a correct characterization of gene expression profiles that may affect metabolic health of colorectal cancer patients.
LB  - PUB:(DE-HGF)16
C6  - pmid:31225875
DO  - DOI:10.1210/jc.2019-00461
UR  - https://inrepo02.dkfz.de/record/144058
ER  -