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@ARTICLE{Meagher:144152,
      author       = {N. S. Meagher and L. Wang and P. F. Rambau and M. P.
                      Intermaggio and D. G. Huntsman and L. R. Wilkens and M. A.
                      El-Bahrawy and R. B. Ness and K. Odunsi and H. Steed and E.
                      Herpel and M. S. Anglesio and B. Zhang and N. Lambie and A.
                      J. Swerdlow and J. Lubiński and R. A. Vierkant and E. L.
                      Goode and U. Menon and A. Toloczko-Grabarek and O. Oszurek
                      and S. Bilic and A. Talhouk and M. García-Closas and Q.
                      Wang and A. Tan and R. Farrell and C. J. Kennedy and M.
                      Jimenez-Linan and K. Sundfeldt and J. L. Etter and J.
                      Menkiszak and M. T. Goodman and P. Klonowski and Y. Leung
                      and S. J. Winham and K. B. Moysich and S. Behrens$^*$ and T.
                      Kluz and R. P. Edwards and J. Gronwald and F. Modugno and B.
                      Y. Hernandez and C. Chow and L. E. Kelemen and G. L. Keeney
                      and M. E. Carney and Y. Natanzon and G. Robertson and R.
                      Sharma and S. A. Gayther and J. Alsop and H. Luk and C.
                      Karpinskyj and I. Campbell and P. Sinn and A. Gentry-Maharaj
                      and P. Coulson and J. Chang-Claude$^*$ and M. Shah and M.
                      Widschwendter and K. Tang and M. J. Schoemaker and J. M.
                      Koziak and L. S. Cook and J. D. Brenton and F. Daley and B.
                      Kristjansdottir and C. Mateoiu and M. C. Larson and P. R.
                      Harnett and A. Jung$^*$ and A. deFazio and K. L. Gorringe
                      and P. D. P. Pharoah and P. Minoo and C. Stewart and O. F.
                      Bathe and X. Gui and P. Cohen and S. J. Ramus and M. Köbel},
      title        = {{A} combination of the immunohistochemical markers {CK}7
                      and {SATB}2 is highly sensitive and specific for
                      distinguishing primary ovarian mucinous tumors from
                      colorectal and appendiceal metastases.},
      journal      = {Modern pathology},
      volume       = {32},
      number       = {12},
      issn         = {1530-0285},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2019-01701},
      pages        = {1834-1846},
      year         = {2019},
      note         = {2019 Dec;32(12):1834-1846},
      abstract     = {Primary ovarian mucinous tumors can be difficult to
                      distinguish from metastatic gastrointestinal neoplasms by
                      histology alone. The expected immunoprofile of a suspected
                      metastatic lower gastrointestinal tumor is
                      CK7-/CK20+/CDX2+/PAX8-. This study assesses the addition of
                      a novel marker SATB2, to improve the diagnostic algorithm. A
                      test cohort included 155 ovarian mucinous tumors (105
                      carcinomas and 50 borderline tumors) and 230 primary lower
                      gastrointestinal neoplasms (123 colorectal adenocarcinomas
                      and 107 appendiceal neoplasms). All cases were assessed for
                      SATB2, PAX8 CK7, CK20, and CDX2 expression on tissue
                      microarrays. Expression was scored in a 3-tier system as
                      absent, focal $(1-50\%$ of tumor cells) and diffuse
                      $( >50\%$ of tumor cells) and then categorized into either
                      absent/present or nondiffuse/diffuse. SATB2 and PAX8
                      expression was further evaluated in ovarian tumors from an
                      international cohort of 2876 patients (expansion cohort,
                      including 159 mucinous carcinomas and 46 borderline mucinous
                      tumors). The highest accuracy of an individual marker
                      in distinguishing lower gastrointestinal from ovarian
                      mucinous tumors was CK7 $(91.7\%,$ nondiffuse/diffuse
                      cut-off) followed by SATB2 $(88.8\%,$ present/absent
                      cut-off). The most effective combination was CK7 and SATB2
                      with accuracy of $95.3\%$ using the 3-tier interpretation,
                      absent/focal/diffuse. This combination outperformed the
                      standard clinical set of CK7, CK20 and CDX2 $(87.5\%).$
                      Re-evaluation of outlier cases confirmed ovarian origin for
                      all but one case. The accuracy of SATB2 was confirmed in the
                      expansion cohort $(91.5\%).$ SATB2 expression was also
                      detected in $15\%$ of ovarian endometrioid carcinoma but
                      less than $5\%$ of other ovarian histotypes. A simple two
                      marker combination of CK7 and SATB2 can distinguish lower
                      gastrointestinal from ovarian primary mucinous tumors with
                      greater than $95\%$ accuracy. PAX8 and CDX2 have value as
                      second-line markers. The utility of CK20 in this setting is
                      low and this warrants replacement of this marker with SATB2
                      in clinical practice.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31239549},
      doi          = {10.1038/s41379-019-0302-0},
      url          = {https://inrepo02.dkfz.de/record/144152},
}