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@ARTICLE{Griessinger:144225,
      author       = {C. M. Griessinger and A. M. Schmid and D. Sonanini and B.
                      F. Schörg and M. A. Jarboui and D. Bukala and N. Mucha and
                      B. Fehrenbacher and J. Steinhilber and M. Martella and U.
                      Kohlhofer and M. Schaller and L. Zender$^*$ and H.-G.
                      Rammensee$^*$ and L. Quintanilla-Martinez and M. Röcken and
                      M. Kneilling and B. J. Pichler},
      title        = {{T}he administration route of tumor-antigen-specific
                      {T}-helper cells differentially modulates the tumor
                      microenvironment and senescence.},
      journal      = {Carcinogenesis},
      volume       = {40},
      number       = {2},
      issn         = {1460-2180},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-01745},
      pages        = {289 - 302},
      year         = {2019},
      abstract     = {Cancer treatment with adoptively transferred
                      tumor-associated antigen-specific CD4+ T-helper cells is a
                      promising immunotherapeutic approach. In the pancreatic
                      cancer model RIP-Tag2, the intraperitoneal (i.p.)
                      application of Tag-specific TH1 cells exhibited a profound
                      antitumoral efficiency. We investigated, whether an
                      intravenous (i.v.) application of Tag-TH1 cells induces an
                      equivalent therapeutic effect. Adoptively transferred
                      fluorescent Tag-TH1 cells revealed a pronounced homing to
                      the tumors after either i.p. or i.v. transfer, and both
                      routes induced an almost equivalent therapeutic effect as
                      demonstrated by magnetic resonance imaging, blood glucose
                      level course and histology. The i.v. administration of
                      Tag-TH1 cells induced p16INK4-positive/Ki67-negative tumor
                      senescence more efficiently than i.p. administration. Both
                      routes replenish host CD4+ T cells by transferred T cells
                      and recruitment of B and dendritic cells to the tumors while
                      reducing CD8+ T cells and depleting macrophages. Both
                      administration routes efficiently induced a similar
                      antitumoral efficiency despite the pronounced senescence
                      induction after i.v. administration. Thus, a combinatory
                      i.v./i.p. injection of therapeutic cells might overcome
                      limitations of the individual routes and improve therapeutic
                      efficacy in solid tumors.},
      cin          = {V076 / L801},
      ddc          = {610},
      cid          = {I:(DE-He78)V076-20160331 / I:(DE-He78)L801-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30753335},
      doi          = {10.1093/carcin/bgy161},
      url          = {https://inrepo02.dkfz.de/record/144225},
}