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@ARTICLE{Koerber:144387,
      author       = {S. A. Koerber and G. Stach and C. Kratochwil and M. F.
                      Haefner and H. Rathke and K. Herfarth and K. Kopka$^*$ and
                      T. Holland-Letz$^*$ and P. L. Choyke and L. Will and U.
                      Haberkorn$^*$ and J. Debus$^*$ and F. Giesel$^*$},
      title        = {{L}ymph node involvement in treatment-naïve prostate
                      cancer patients - correlation of {PSMA}-{PET}/{CT} imaging
                      and {R}oach formula in 280 men in the {R}adiotherapeutic
                      management.},
      journal      = {Journal of nuclear medicine},
      volume       = {61},
      number       = {1},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2019-01840},
      pages        = {46-50},
      year         = {2020},
      note         = {2020 Jan;61(1):46-50#LA:E060#},
      abstract     = {The importance of PSMA-PET/CT for primary staging of
                      treatment-naïve prostate cancer patients is still under
                      debate. Therefore, the present study aimed to evaluate the
                      role of PSMA PET/CT in detecting nodal metastases in a large
                      cohort of men and compare imaging results with the risk of
                      lymph node involvement based on the Roach formula. Methods:
                      In total, 280 men with newly diagnosed prostate carcinoma
                      were included in the present study. For all patients
                      PSMA-PET/CT was performed for primary staging. Median age
                      was 67 years (range 38 - 84 years), $84\%$ of all patients
                      were classified as high-risk according to d'Amico. The risk
                      of lymph node involvement was calculated using the Roach
                      formula and compared to the PSMA-PET/CT results. Results:
                      PSMA-positive nodes were detected in 90 of 280 men
                      $(32.1\%).$ While the majority of nodal metastases occurred
                      within the pelvis, $35.5\%$ were observed in extrapelvic
                      sites. In 9 patients $(3.2\%),$ nodal metastases occurred in
                      the Virchow node. After comparison of PSMA data with the
                      results of the Roach formula, an area under the curve (AUC)
                      of 0.781 was obtained for the Roach predictions. Conclusion:
                      For treatment-naïve prostate cancer patients, PSMA-PET/CT
                      is well suited for the detection of nodal metastases.
                      However, the original Roach formula can still be used for a
                      quick assessment of potential lymphatic spread in daily
                      clinical routine.},
      cin          = {E060 / E030 / HD01 / C060 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)E030-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)E050-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31302638},
      doi          = {10.2967/jnumed.119.227637},
      url          = {https://inrepo02.dkfz.de/record/144387},
}