% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Oswald:144397,
      author       = {E. Oswald$^*$ and M. Kirschberg and F. Aubin and A.
                      Alonso$^*$ and M. Hufbauer and B. Akgül and E. Auvinen},
      title        = {{B}eta{HPV} {E}6 and {E}7 colocalize with {N}u{M}a in
                      dividing keratinocytes.},
      journal      = {Virus genes},
      volume       = {55},
      number       = {5},
      issn         = {1572-994X},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DKFZ-2019-01850},
      pages        = {600-609},
      year         = {2019},
      abstract     = {Human papillomaviruses (HPVs) of genus betapapillomavirus
                      (betaHPV) are implicated in skin carcinogenesis, but their
                      exact role in keratinocyte transformation is poorly
                      understood. We show an interaction of HPV5 and HPV8
                      oncoproteins E6 and E7 with the nuclear mitotic apparatus
                      protein 1 (NuMA). Binding of E6 or E7 to NuMA induces little
                      aneuploidy, cell cycle alterations, or aberrant centrosomes.
                      Intracellular localization of NuMA is not altered by E6 and
                      E7 expression in 2D cultures. However, the localization
                      profile is predominantly cytoplasmic in 3D organotypic skin
                      models. Both viral proteins colocalize with NuMA in
                      interphase cells, while only E7 colocalizes with NuMA in
                      mitotic cells. Intriguingly, a small subset of cells shows
                      E7 at only one spindle pole, whereas NuMA is present at both
                      poles. This dissimilar distribution of E7 at the spindle
                      poles may alter cell differentiation, which may in turn be
                      relevant for betaHPV-induced skin carcinogenesis.},
      cin          = {F050},
      ddc          = {610},
      cid          = {I:(DE-He78)F050-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31290065},
      doi          = {10.1007/s11262-019-01685-9},
      url          = {https://inrepo02.dkfz.de/record/144397},
}