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@ARTICLE{Richter:144403,
      author       = {K. Richter$^*$ and Y. T. Kschonsak$^*$ and B. Vodicska$^*$
                      and I. Hoffmann$^*$},
      title        = {{FBXO}45-{MYCBP}2 regulates mitotic cell fate by targeting
                      {FBXW}7 for degradation.},
      journal      = {Cell death and differentiation},
      volume       = {27},
      number       = {2},
      issn         = {1476-5403},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {DKFZ-2019-01856},
      pages        = {758-772},
      year         = {2020},
      note         = {2020 Feb;27(2):758-772#EA:F045#LA:F045#},
      abstract     = {Cell fate decision upon prolonged mitotic arrest induced by
                      microtubule-targeting agents depends on the activity of the
                      tumor suppressor and F-box protein FBXW7. FBXW7 promotes
                      mitotic cell death and prevents premature escape from
                      mitosis through mitotic slippage. Mitotic slippage is a
                      process that can cause chemoresistance and tumor relapse.
                      Therefore, understanding the mechanisms that regulate the
                      balance between mitotic cell death and mitotic slippage is
                      an important task. Here we report that FBXW7 protein levels
                      markedly decline during extended mitotic arrest. FBXO45
                      binds to a conserved acidic N-terminal motif of FBXW7
                      specifically under a prolonged delay in mitosis, leading to
                      ubiquitylation and subsequent proteasomal degradation of
                      FBXW7 by the FBXO45-MYCBP2 E3 ubiquitin ligase. Moreover, we
                      find that FBXO45-MYCBP2 counteracts FBXW7 in that it
                      promotes mitotic slippage and prevents cell death in
                      mitosis. Targeting this interaction represents a promising
                      strategy to prevent chemotherapy resistance.},
      cin          = {F045},
      ddc          = {610},
      cid          = {I:(DE-He78)F045-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31285543},
      doi          = {10.1038/s41418-019-0385-7},
      url          = {https://inrepo02.dkfz.de/record/144403},
}