% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Christakoudi:144418,
      author       = {S. Christakoudi and A. Kakourou and G. Markozannes and I.
                      Tzoulaki and E. Weiderpass and P. Brennan and M. Gunter and
                      C. C. Dahm and K. Overvad and A. Olsen and A. Tjønneland
                      and M.-C. Boutron-Ruault and A.-L. Madika and G. Severi and
                      V. Katzke$^*$ and T. Kühn$^*$ and M. M. Bergmann and H.
                      Boeing and A. Karakatsani and G. Martimianaki and P.
                      Thriskos and G. Masala and S. Sieri and S. Panico and R.
                      Tumino and F. Ricceri and A. Agudo and D. Redondo-Sánchez
                      and S. M. Colorado-Yohar and O. Mokoroa and O. Melander and
                      T. Stocks and C. Häggström and S. Harlid and B.
                      Bueno-de-Mesquita and C. H. van Gils and R. C. H. Vermeulen
                      and K.-T. Khaw and N. J. Wareham and T. Y. N. Tong and H.
                      Freisling and M. Johansson and H. Lennon and D. Aune and E.
                      Riboli and D. Trichopoulos and A. Trichopoulou and K. K.
                      Tsilidis},
      title        = {{B}lood pressure and risk of cancer in the {E}uropean
                      {P}rospective {I}nvestigation into {C}ancer and
                      {N}utrition.},
      journal      = {International journal of cancer},
      volume       = {146},
      number       = {10},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-01871},
      pages        = {2680-2693},
      year         = {2020},
      note         = {2020 May 15;146(10):2680-2693},
      abstract     = {Several studies have reported associations of hypertension
                      with cancer, but not all results were conclusive. We
                      examined the association of systolic (SBP) and diastolic
                      (DBP) blood pressure with the development of incident cancer
                      at all anatomical sites in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC). Hazard
                      ratios (HR) $(95\%$ confidence intervals) were estimated
                      using multivariable Cox proportional hazards models,
                      stratified by EPIC-participating centre and age at
                      recruitment, and adjusted for sex, education, smoking, body
                      mass index, physical activity, diabetes and dietary (in
                      women also reproductive) factors. The study included 307,318
                      men and women, with an average follow-up of 13.7 (standard
                      deviation 4.4) years and 39,298 incident cancers. We
                      confirmed the expected positive association with renal cell
                      carcinoma: HR=1.12 (1.08-1.17) per 10mmHg higher SBP and
                      HR=1.23 (1.14-1.32) for DBP. We additionally found positive
                      associations for esophageal squamous cell carcinoma (SCC):
                      HR=1.16 (1.07-1.26) (SBP), HR=1.31 (1.13-1.51) (DBP), weaker
                      for head and neck cancers: HR=1.08 (1.04-1.12) (SBP),
                      HR=1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC,
                      colon cancer, post-menopausal breast cancer and uterine
                      adenocarcinoma (AC), but not for esophageal AC, lung SCC,
                      lung AC, or uterine endometroid cancer. We observed weak
                      inverse associations of SBP with cervical SCC: HR=0.91
                      (0.82-1.00) and lymphomas: HR=0.97 (0.93-1.00). There were
                      no consistent associations with cancers in other locations.
                      Our results are largely compatible with published studies
                      and support weak associations of blood pressure with cancers
                      in specific locations and morphologies. This article is
                      protected by copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31319002},
      doi          = {10.1002/ijc.32576},
      url          = {https://inrepo02.dkfz.de/record/144418},
}