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@ARTICLE{ZamoraRos:144447,
      author       = {R. Zamora-Ros and V. Cayssials and S. Franceschi and C.
                      Kyrø and E. Weiderpass and J. Hennings and M. Sandström
                      and A. Tjønneland and A. Olsen and K. Overvad and M.-C.
                      Boutron-Ruault and T. Truong and F. R. Mancini and V.
                      Katzke$^*$ and T. Kühn$^*$ and H. Boeing and A.
                      Trichopoulou and A. Karakatsani and G. Martimianaki and D.
                      Palli and V. Krogh and S. Panico and R. Tumino and C.
                      Sacerdote and C. Lasheras and M. Rodríguez-Barranco and P.
                      Amiano and S. M. Colorado-Yohar and E. Ardanaz and M.
                      Almquist and U. Ericson and H. B. Bueno-de-Mesquita and R.
                      Vermeulen and J. A. Schmidt and G. Byrnes and A. Scalbert
                      and A. Agudo and S. Rinaldi},
      title        = {{P}olyphenol intake and differentiated thyroid cancer risk
                      in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}) cohort.},
      journal      = {International journal of cancer},
      volume       = {146},
      number       = {7},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-01899},
      pages        = {1841-1850},
      year         = {2020},
      note         = {2020 Apr 1;146(7):1841-1850},
      abstract     = {Polyphenols are bioactive compounds with several
                      anticarcinogenic activities; however, human data regarding
                      associations with thyroid cancer (TC) is still negligible.
                      Our aim was to evaluate the association between intakes of
                      total, classes and subclasses of polyphenols and risk of
                      differentiated TC and its main subtypes, papillary and
                      follicular, in a European population. The European
                      Prospective Investigation into Cancer and Nutrition cohort
                      included 476,108 men and women from 10 European countries.
                      During a mean follow-up of 14 years, there were 748
                      incident differentiated TC cases, including 601 papillary
                      and 109 follicular tumors. Polyphenol intake was estimated
                      at baseline using validated center/country-specific dietary
                      questionnaires and the Phenol-Explorer database. In
                      multivariable-adjusted Cox regression models, no association
                      between total polyphenol and the risks of overall
                      differentiated TC (HRQ4 vs. Q1 = 0.99, $95\%$ confidence
                      interval [CI] 0.77-1.29), papillary (HRQ4 vs. Q1 = 1.06,
                      $95\%$ CI 0.80-1.41) or follicular TC (HRQ4 vs. Q1 = 1.10,
                      $95\%$ CI 0.55-2.22) were found. No associations were
                      observed either for flavonoids, phenolic acids or the rest
                      of classes and subclasses of polyphenols. After
                      stratification by body mass index (BMI), an inverse
                      association between the intake of polyphenols (p-trend =
                      0.019) and phenolic acids (p-trend = 0.007) and
                      differentiated TC risk in subjects with BMI ≥ 25 was
                      observed. In conclusion, our study showed no associations
                      between dietary polyphenol intake and differentiated TC
                      risk; although further studies are warranted to investigate
                      the potential protective associations in overweight and
                      obese individuals.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31342519},
      doi          = {10.1002/ijc.32589},
      url          = {https://inrepo02.dkfz.de/record/144447},
}