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000144450 1001_ $$aHovestadt, Volker$$b0
000144450 245__ $$aResolving medulloblastoma cellular architecture by single-cell genomics.
000144450 260__ $$aLondon [u.a.]$$bNature Publ. Group52462$$c2019
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000144450 520__ $$aMedulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their divergent biology and clinical behaviour remains largely unexplored. Here we used single-cell transcriptomics to investigate intra- and intertumoral heterogeneity in 25 medulloblastomas spanning all molecular subgroups. WNT, SHH and Group 3 tumours comprised subgroup-specific undifferentiated and differentiated neuronal-like malignant populations, whereas Group 4 tumours consisted exclusively of differentiated neuronal-like neoplastic cells. SHH tumours closely resembled granule neurons of varying differentiation states that correlated with patient age. Group 3 and Group 4 tumours exhibited a developmental trajectory from primitive progenitor-like to more mature neuronal-like cells, the relative proportions of which distinguished these subgroups. Cross-species transcriptomics defined distinct glutamatergic populations as putative cells-of-origin for SHH and Group 4 subtypes. Collectively, these data provide insights into the cellular and developmental states underlying subtype-specific medulloblastoma biology.
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000144450 7001_ $$aSmith, Kyle S$$b1
000144450 7001_ $$aBihannic, Laure$$b2
000144450 7001_ $$aFilbin, Mariella G$$b3
000144450 7001_ $$aShaw, McKenzie L$$b4
000144450 7001_ $$aBaumgartner, Alicia$$b5
000144450 7001_ $$aDeWitt, John C$$b6
000144450 7001_ $$aGroves, Andrew$$b7
000144450 7001_ $$aMayr, Lisa$$b8
000144450 7001_ $$aWeisman, Hannah R$$b9
000144450 7001_ $$aRichman, Alyssa R$$b10
000144450 7001_ $$aShore, Marni E$$b11
000144450 7001_ $$aGoumnerova, Liliana$$b12
000144450 7001_ $$aRosencrance, Celeste$$b13
000144450 7001_ $$aCarter, Robert A$$b14
000144450 7001_ $$aPhoenix, Timothy N$$b15
000144450 7001_ $$aHadley, Jennifer L$$b16
000144450 7001_ $$aTong, Yiai$$b17
000144450 7001_ $$aHouston, Jim$$b18
000144450 7001_ $$aAshmun, Richard A$$b19
000144450 7001_ $$aDeCuypere, Michael$$b20
000144450 7001_ $$0P:(DE-He78)36e1ec4777d5b7887344177dca41eae9$$aSharma, Tanvi$$b21$$udkfz
000144450 7001_ $$aFlasch, Diane$$b22
000144450 7001_ $$aSilkov, Antonina$$b23
000144450 7001_ $$aLigon, Keith L$$b24
000144450 7001_ $$aPomeroy, Scott L$$b25
000144450 7001_ $$aRivera, Miguel N$$b26
000144450 7001_ $$aRozenblatt-Rosen, Orit$$b27
000144450 7001_ $$aRusert, Jessica M$$b28
000144450 7001_ $$aWechsler-Reya, Robert J$$b29
000144450 7001_ $$aLi, Xiao-Nan$$b30
000144450 7001_ $$aPeyrl, Andreas$$b31
000144450 7001_ $$aGojo, Johannes$$b32
000144450 7001_ $$aKirchhofer, Dominik$$b33
000144450 7001_ $$aLötsch, Daniela$$b34
000144450 7001_ $$aCzech, Thomas$$b35
000144450 7001_ $$aDorfer, Christian$$b36
000144450 7001_ $$aHaberler, Christine$$b37
000144450 7001_ $$aGeyeregger, Rene$$b38
000144450 7001_ $$aHalfmann, Angela$$b39
000144450 7001_ $$aGawad, Charles$$b40
000144450 7001_ $$aEaston, John$$b41
000144450 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b42$$udkfz
000144450 7001_ $$aRegev, Aviv$$b43
000144450 7001_ $$aGajjar, Amar$$b44
000144450 7001_ $$aOrr, Brent A$$b45
000144450 7001_ $$aSlavc, Irene$$b46
000144450 7001_ $$aRobinson, Giles W$$b47
000144450 7001_ $$aBernstein, Bradley E$$b48
000144450 7001_ $$aSuvà, Mario L$$b49
000144450 7001_ $$aNorthcott, Paul A$$b50
000144450 773__ $$0PERI:(DE-600)1413423-8$$a10.1038/s41586-019-1434-6$$gVol. 572, no. 7767, p. 74 - 79$$n7767$$p74 - 79$$tNature <London>$$v572$$x1476-4687$$y2019
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