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@ARTICLE{Hovestadt:144450,
      author       = {V. Hovestadt and K. S. Smith and L. Bihannic and M. G.
                      Filbin and M. L. Shaw and A. Baumgartner and J. C. DeWitt
                      and A. Groves and L. Mayr and H. R. Weisman and A. R.
                      Richman and M. E. Shore and L. Goumnerova and C. Rosencrance
                      and R. A. Carter and T. N. Phoenix and J. L. Hadley and Y.
                      Tong and J. Houston and R. A. Ashmun and M. DeCuypere and T.
                      Sharma$^*$ and D. Flasch and A. Silkov and K. L. Ligon and
                      S. L. Pomeroy and M. N. Rivera and O. Rozenblatt-Rosen and
                      J. M. Rusert and R. J. Wechsler-Reya and X.-N. Li and A.
                      Peyrl and J. Gojo and D. Kirchhofer and D. Lötsch and T.
                      Czech and C. Dorfer and C. Haberler and R. Geyeregger and A.
                      Halfmann and C. Gawad and J. Easton and S. M. Pfister$^*$
                      and A. Regev and A. Gajjar and B. A. Orr and I. Slavc and G.
                      W. Robinson and B. E. Bernstein and M. L. Suvà and P. A.
                      Northcott},
      title        = {{R}esolving medulloblastoma cellular architecture by
                      single-cell genomics.},
      journal      = {Nature},
      volume       = {572},
      number       = {7767},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group52462},
      reportid     = {DKFZ-2019-01902},
      pages        = {74 - 79},
      year         = {2019},
      abstract     = {Medulloblastoma is a malignant childhood cerebellar tumour
                      type that comprises distinct molecular subgroups. Whereas
                      genomic characteristics of these subgroups are well defined,
                      the extent to which cellular diversity underlies their
                      divergent biology and clinical behaviour remains largely
                      unexplored. Here we used single-cell transcriptomics to
                      investigate intra- and intertumoral heterogeneity in 25
                      medulloblastomas spanning all molecular subgroups. WNT, SHH
                      and Group 3 tumours comprised subgroup-specific
                      undifferentiated and differentiated neuronal-like malignant
                      populations, whereas Group 4 tumours consisted exclusively
                      of differentiated neuronal-like neoplastic cells. SHH
                      tumours closely resembled granule neurons of varying
                      differentiation states that correlated with patient age.
                      Group 3 and Group 4 tumours exhibited a developmental
                      trajectory from primitive progenitor-like to more mature
                      neuronal-like cells, the relative proportions of which
                      distinguished these subgroups. Cross-species transcriptomics
                      defined distinct glutamatergic populations as putative
                      cells-of-origin for SHH and Group 4 subtypes. Collectively,
                      these data provide insights into the cellular and
                      developmental states underlying subtype-specific
                      medulloblastoma biology.},
      cin          = {B062 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31341285},
      doi          = {10.1038/s41586-019-1434-6},
      url          = {https://inrepo02.dkfz.de/record/144450},
}