guest ::
| Home > Publications database > Resolving medulloblastoma cellular architecture by single-cell genomics. > print |
| Home > Publications database > Resolving medulloblastoma cellular architecture by single-cell genomics. > print |
| 001 | 144450 | ||
| 005 | 20240229112625.0 | ||
| 024 | 7 | _ | |a 10.1038/s41586-019-1434-6 |2 doi |
| 024 | 7 | _ | |a pmid:31341285 |2 pmid |
| 024 | 7 | _ | |a 0028-0836 |2 ISSN |
| 024 | 7 | _ | |a 1476-4687 |2 ISSN |
| 024 | 7 | _ | |a altmetric:63988388 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2019-01902 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Hovestadt, Volker |b 0 |
| 245 | _ | _ | |a Resolving medulloblastoma cellular architecture by single-cell genomics. |
| 260 | _ | _ | |a London [u.a.] |c 2019 |b Nature Publ. Group52462 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1577107977_20113 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their divergent biology and clinical behaviour remains largely unexplored. Here we used single-cell transcriptomics to investigate intra- and intertumoral heterogeneity in 25 medulloblastomas spanning all molecular subgroups. WNT, SHH and Group 3 tumours comprised subgroup-specific undifferentiated and differentiated neuronal-like malignant populations, whereas Group 4 tumours consisted exclusively of differentiated neuronal-like neoplastic cells. SHH tumours closely resembled granule neurons of varying differentiation states that correlated with patient age. Group 3 and Group 4 tumours exhibited a developmental trajectory from primitive progenitor-like to more mature neuronal-like cells, the relative proportions of which distinguished these subgroups. Cross-species transcriptomics defined distinct glutamatergic populations as putative cells-of-origin for SHH and Group 4 subtypes. Collectively, these data provide insights into the cellular and developmental states underlying subtype-specific medulloblastoma biology. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Smith, Kyle S |b 1 |
| 700 | 1 | _ | |a Bihannic, Laure |b 2 |
| 700 | 1 | _ | |a Filbin, Mariella G |b 3 |
| 700 | 1 | _ | |a Shaw, McKenzie L |b 4 |
| 700 | 1 | _ | |a Baumgartner, Alicia |b 5 |
| 700 | 1 | _ | |a DeWitt, John C |b 6 |
| 700 | 1 | _ | |a Groves, Andrew |b 7 |
| 700 | 1 | _ | |a Mayr, Lisa |b 8 |
| 700 | 1 | _ | |a Weisman, Hannah R |b 9 |
| 700 | 1 | _ | |a Richman, Alyssa R |b 10 |
| 700 | 1 | _ | |a Shore, Marni E |b 11 |
| 700 | 1 | _ | |a Goumnerova, Liliana |b 12 |
| 700 | 1 | _ | |a Rosencrance, Celeste |b 13 |
| 700 | 1 | _ | |a Carter, Robert A |b 14 |
| 700 | 1 | _ | |a Phoenix, Timothy N |b 15 |
| 700 | 1 | _ | |a Hadley, Jennifer L |b 16 |
| 700 | 1 | _ | |a Tong, Yiai |b 17 |
| 700 | 1 | _ | |a Houston, Jim |b 18 |
| 700 | 1 | _ | |a Ashmun, Richard A |b 19 |
| 700 | 1 | _ | |a DeCuypere, Michael |b 20 |
| 700 | 1 | _ | |a Sharma, Tanvi |0 P:(DE-He78)36e1ec4777d5b7887344177dca41eae9 |b 21 |u dkfz |
| 700 | 1 | _ | |a Flasch, Diane |b 22 |
| 700 | 1 | _ | |a Silkov, Antonina |b 23 |
| 700 | 1 | _ | |a Ligon, Keith L |b 24 |
| 700 | 1 | _ | |a Pomeroy, Scott L |b 25 |
| 700 | 1 | _ | |a Rivera, Miguel N |b 26 |
| 700 | 1 | _ | |a Rozenblatt-Rosen, Orit |b 27 |
| 700 | 1 | _ | |a Rusert, Jessica M |b 28 |
| 700 | 1 | _ | |a Wechsler-Reya, Robert J |b 29 |
| 700 | 1 | _ | |a Li, Xiao-Nan |b 30 |
| 700 | 1 | _ | |a Peyrl, Andreas |b 31 |
| 700 | 1 | _ | |a Gojo, Johannes |b 32 |
| 700 | 1 | _ | |a Kirchhofer, Dominik |b 33 |
| 700 | 1 | _ | |a Lötsch, Daniela |b 34 |
| 700 | 1 | _ | |a Czech, Thomas |b 35 |
| 700 | 1 | _ | |a Dorfer, Christian |b 36 |
| 700 | 1 | _ | |a Haberler, Christine |b 37 |
| 700 | 1 | _ | |a Geyeregger, Rene |b 38 |
| 700 | 1 | _ | |a Halfmann, Angela |b 39 |
| 700 | 1 | _ | |a Gawad, Charles |b 40 |
| 700 | 1 | _ | |a Easton, John |b 41 |
| 700 | 1 | _ | |a Pfister, Stefan M |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 42 |u dkfz |
| 700 | 1 | _ | |a Regev, Aviv |b 43 |
| 700 | 1 | _ | |a Gajjar, Amar |b 44 |
| 700 | 1 | _ | |a Orr, Brent A |b 45 |
| 700 | 1 | _ | |a Slavc, Irene |b 46 |
| 700 | 1 | _ | |a Robinson, Giles W |b 47 |
| 700 | 1 | _ | |a Bernstein, Bradley E |b 48 |
| 700 | 1 | _ | |a Suvà, Mario L |b 49 |
| 700 | 1 | _ | |a Northcott, Paul A |b 50 |
| 773 | _ | _ | |a 10.1038/s41586-019-1434-6 |g Vol. 572, no. 7767, p. 74 - 79 |0 PERI:(DE-600)1413423-8 |n 7767 |p 74 - 79 |t Nature |v 572 |y 2019 |x 1476-4687 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:144450 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-He78)36e1ec4777d5b7887344177dca41eae9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 42 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NATURE : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 40 |0 StatID:(DE-HGF)9940 |2 StatID |b NATURE : 2017 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|